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Tools to analyze nuclear function,
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MODified™ Histone Peptide Array

Screen antibodies, enzymes and proteins for
binding interactions with histones and 59 specific
acetylation, methylation, phosphorylation and
citrullination modifications. With up to 4 modifications
per peptide, 384 different combinations are included.

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MODified Histone Peptide Array

Next-Gen Sequencing of

Methylated DNA

Active Motif's MeDIP and MethylCollector™ Ultra Kits
specifically enrich for methylated DNA fragments that are
ideal for use in MeDIP-Seq and MIRA-Seq.

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Next-Gen of Enriched Methylated DNA

Study miRNA-3´UTR Interactions

The LightSwitch™ 3´UTR Reporter Collection includes
over 12,000 3´UTRs cloned from the human genome into
ready-to-transfect reporter vectors. Combined with our large
collections of miRNA Mimics and Inhibitors, you have
everything needed to study miRNA-3´UTR interactions.

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LightSwitch 3'UTR-miRNA Interactions

Transcription Factor Assays

TransAM® Kits are DNA-binding assays that facilitate
the study of transcription factor activation in mammalian
tissue and cell culture extracts. TransAM has
been cited in over 800 papers, making
it the overwhelming method of choice.

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TransAM DNA-binding ELISAs

No Sonicator? No Problem!

ChIP-IT® Express Enzymatic is our easiest-to-use ChIP kit.
It features our user-friendly method to shear chromatin by
enzymatic digestion, so you don't even need a sonicator.
It also utilizes protein G-coated magnetic beads, reducing the
time required to perform ChIP while improving your results.

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ChIP-IT Express

Imaging & Isolation of Stem Cells

The Stem Cell CDy1 Dye selectively stains
pluripotent stem cells
, making it simple to
detect and isolate live mESCs, hESCs or iPSCs
from feeder cells and mixed cultures using
fluorescence microscopy or FACS analysis.

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Stem Cell CDy1 Dye

Monoclonal antibodies from Active Motif

New & Notable Products for Epigenetics,
Chromatin Biology and Gene Regulation

  • Activators and Inhibitors for Epigenetic Research

    Active Motif now offers a collection of Epigenetic Activators and Inhibitors. These include small molecules that target HATs, HDACs, HMTs, HDMs, Sirtuins and DNA methylation. These epigenetic modulators represent an important tool for researchers performing both mechanistic and drug discovery assays. More >

  • PBMC ChIP Kit offers a complete solution for ChIP from B and T cells

    PBMCs (peripheral blood mononuclear cells), like other primary cells, are notoriously difficult to lyse which presents a challenge for chromatin preparation for ChIP. Active Motif's new ChIP-IT® PBMC Kit is the first commercial kit available that offers a complete solution for the ChIP assay workflow by providing reagents and protocols for chromatin preparation, ChIP and DNA purification that have been specifically formulated to work with PBMCs such as lymphocytes (T cells, B cells and NK cells) and monocytes. More >

  • NOMe-Seq – A Top Ten Innovations 2013 winner by The Scientist

    NOMe-Seq is the first commercially available assay to study nucleosome occupancy and CpG methylation status simultaneously on the same DNA strand. More >

  • Rapid Bisulfite Conversion Kit for single-nucleotide DNA methylation analysis, including positive control primers for validation

    Active Motif's Bisulfite Conversion Kit is a rapid 1.5 hour conversion protocol to convert unmethylated cytosines into uracil for single-nucleotide DNA methylation analysis. More >

  • Post-transcriptional Regulation Mediated by miRNA-3´UTR Interactions

    While gene regulation studies have historically focused on events that influence transcription, post-transcriptional regulation plays an equally important role. The binding of miRNAs to the 3´UTRs of transcribed mRNAs affect both the transcript’s stability and rate of translation. To study miRNA-3´UTR interactions, Active Motif offers over 12,000 LightSwitch™ 3´UTR Reporter constructs, as well as over 900 synthetic miRNA targets, and 1000 miRNA mimics & inhibitors. More >

  • Obtain ChIP-Seq Data from FFPE Tissue Samples

    Active Motif's new ChIP-IT® FFPE Chromatin Preparation Kit and ChIP-IT® FFPE Kit are the first kits available to perform ChIP analysis of formalin-fixed paraffin-embedded (FFPE) tissue material. Due to the limited size and harsh fixation conditions used to prepare FFPE slides and tissue blocks, these samples have previously not been useful in ChIP. Active Motif's new assays are the only kits with the sensitivity required to obtain ChIP-Seq quality DNA from FFPE tissues. More >

  • New Luminex® Multiplex Assay to Screen Histone PTMs

    Active Motif has partnered with Luminex® to develop a 96-well plate-based multiplex assay for the analysis of histone PTMs. The Histone PTM Multiplex Kit enables simultaneous analysis of up to 13 different Histone H3 modifications within the same well using only nanogram quantities of sample. More >

  • More Recombinant Methyltransferases and Demethylases to Choose From

    Active Motif has recently expanded its offering of high-quality Recombinant Histone Methyltransferases (HMTs) and Histone Demethylases (HDMs), including newly added PRC2 complexes (including complexes with EZH2 point mutations), and additional Jumonji, arginine methyltransferases and arginine demethylases. The enzymes are suitable for use in studies of enzyme kinetics, profiling and screening of inhibitors, and drug discovery and development. More >

  • Over 30,000 Pre-Cloned Regulatory Elements for Reporter Assays

    The LightSwitch™ Luciferase Assay System includes over 18,000 promoters and 12,000 3´UTRs cloned from the human genome and available as transfection-ready LightSwitch luciferase reporter vectors. Other LightSwitch products include Pathway Reporter Stable Cell Lines, Synthetic miRNA Targets, and miRNA Mimics and Inhibitors. More >

  • MODified™ Protein Domain Binding Kit to Assay Specificity of Protein Reading Domains

    The MODified™ Protein Domain Binding Kit is designed to be used in combination with Active Motif's MODified Histone Peptide Array to screen His-tagged protein domains for interaction with histone and their post-translational modifications. The kit contains optimized buffers and reagents for analysis of protein domain binding specificity along with HRP-conjugated antibodies and ECL reagents chemiluminescent detection. For added convenience, a positive control tudor domain protein is also provided.More >

  • Novel Stem Cell Dye for the Identification of Live Stem Cells

    Stem Cell CDy1 Dye is designed for selective staining of live stem cells. The CDy1 dye can be used for identification and isolation of various cell types including ESCs, iPSCs, neural stem cells and cancer stem cells by fluorescence imaging or FACS analysis. More >

  • ChIP-IT® ChIP-Seq Kit for Whole-genome ChIP Analysis

    Active Motif now offers a complete workflow for ChIP-Seq experiments with our new ChIP-IT® ChIP-Seq Kit. The Kit provides proven reagents and protocols for successful ChIP-Seq results. More >

  • High Sensitivity ChIP Kit

    Obtain high quality ChIP DNA when working with low abundance transcription factor targets, antibodies with sub-optimal binding affinities or when using as few as 1,000 cells per IP with Active Motif's ChIP-IT® High Sensitivity Kit. More >

  • Study NFκB Activation/Translocation via IκBα Phosphorylation

    Inactive NFκB dimers are sequestered in the cytoplasm by the IκB family of inhibitor proteins, which mask the NFκB nuclear localization signals. Phosphorylation of IκBα in response to various external stimuli enables activated NFκB to translocate to the nucleus and regulate a variety of genes. The FunctionELISA™ IκBα Kit is ideal for studying events that lead to IκBα phosphorylation. More >

  • Ready-to-Use Protein G Agarose Columns for ChIP

    Active Motif's Protein G Agarose Columns contain pre-washed Protein G agarose loaded into columns and ready to use for ChIP. Simply add the ChIP reaction to the column and go. Wash steps are also performed in the column which makes the process faster and also ensures complete sample recovery for better reproducibility. More >

  • Recombinant Bromodomain Proteins

    Active Motif has just introduced a large number of high-quality Recombinant Bromodomain proteins for use in studies of bromodomain function in transcriptional regulation and chromatin remodeling. More >

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Epigenetics News

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