Active Motif,
Tools to analyze nuclear function,
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High Sensitivity ChIP for the Most

Challenging Targets and Samples

ChIP-IT® High Sensitivity provides great ChIP results, even with
difficult-to-ChIP materials, such as low abundance transcription
factors, low-affinity antibodies or limited amounts of starting material.

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DNA Methylation Antibodies

Active Motif offers a large variety of highly
validated antibodies for the study of
DNA methylation in all its forms, including
antibodies against 5-mC, 5-hmC, 5-fC,
5-caC, 3-mC, and a number of DNMTs.

See our DNA Methylation Antibodies
DNA Methylation Antibodies

Transcription Factor Assays

TransAM® Kits are DNA-binding assays that facilitate
the study of transcription factor activation in mammalian
tissue and cell culture extracts. TransAM has
been cited in over 800 papers, making
it the overwhelming method of choice.

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TransAM DNA-binding ELISAs

Study miRNA-3´UTR Interactions

The LightSwitch™ 3´UTR Reporter Collection includes
over 12,000 3´UTRs cloned from the human genome into
ready-to-transfect reporter vectors. Combined with our large
collections of miRNA Mimics and Inhibitors, you have
everything needed to study miRNA-3´UTR interactions.

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LightSwitch 3'UTR-miRNA Interactions

MODified™ Histone Peptide Array

Screen antibodies, enzymes and proteins for
binding interactions with histones and 59 specific
acetylation, methylation, phosphorylation and
citrullination modifications. With up to 4 modifications
per peptide, 384 different combinations are included.

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MODified Histone Peptide Array

Next-Gen Sequencing of

Methylated DNA

Active Motif's MeDIP and MethylCollector™ Ultra Kits
specifically enrich for methylated DNA fragments that are
ideal for use in MeDIP-Seq and MIRA-Seq.

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Next-Gen of Enriched Methylated DNA

Epigenetic regulation implicated in cancer

New Products for Epigenetics Research

  • enChIP Kit to Confirm CRISPR/Cas9 Specificity

    The enChIP Kit uses the CRISPR/Cas9 system to direct a guide RNA (gRNA) and AM-tagged dCas9 protein to a specific genomic locus for immunoprecipitation. enChIP can be used to identify off-target binding effects. More >

  • Quantify Global Changes in 5-hmC

    The Global 5-hmC Quantification Kit is an ELISA-based assay designed to screen for differences in global 5-hydroxymethylcytosine (5-hmC) levels across samples or treatment conditions. The included DNA standards provide quantitative results that are consistent with mass spectrometry. More >

  • Specific Isolation of Nuclear and Cytoplasmic RNA

    The RNA Subcellular Isolation Kit makes it easier to study low abundance RNA transcripts and to demonstrate the role of lncRNA localization with RNA function by providing an efficient method to isolate nuclear or cytoplasmic RNA fractions without cross-contamination. More >

  • Perform ChIP Without Protein-specific Antibodies

    The Tag-ChIP-IT® Kit makes it easy to perform ChIP with transcription factor sequence variants, mutations or truncations by eliminating the need for protein-specific antibodies. Simply clone your protein sequence with Active Motif's unique AM-tag, specifically designed for use in ChIP, transfect your cells and perform ChIP using an antibody directed against the AM-tag. More >

  • Promoter Reporters Validated Using Pathway-specific Inductions

    The LightSwitch™ Validated Pathway Collections contain promoter reporter constructs that were experimentally validated to show significant activation or repression in response to pathway-specific induction conditions, so they are ideal for studying the key promoters that regulate a variety of different pathways, such as inflammation, hypoxia, DNA damage, heat shock, etc. More >

  • Genome-wide Analysis of 5-Hydroxymethylcytosine (5-hmC)

    Active Motif's Hydroxymethyl Collector™–Seq Kit offers a highly sensitive and specific assay for genome-wide analysis of 5-hydroxymethylcytosine. The assay utilizes our proprietary method to label each 5-hmC residue with a modified glucose for specific enrichment. Enriched DNA is ready for use in Next-Generation Sequencing to determine the localization of 5-hmC within the sample. More >

  • Quantify H3K27ac Levels With Our New Histone ELISA

    Histone H3K27 acetylation is a mark of active enhancers. Active Motif offers the first commercially available ELISA to screen for changes in H3K27ac and to quantify the amount of Histone H3 lysine 27 acetylation using our recombinant histone standard. Click to learn more about the Histone H3 acetyl Lys27 ELISA. More >

  • Reduce the Effects of Technical Variation In Your ChIP

    Active Motif has developed a ChIP Normalization Strategy that can be used to normalize ChIP qPCR and ChIP-Seq data to reduce the effects of technical variation and sample processing bias. This normalization strategy can be applied across samples and antibodies. More >

  • Study the Regulation of lncRNA Promoters

    LightSwitch™ lncRNA Promoter Reporter Vectors make it fast and easy to study the unique regulation of lncRNA promoters using Active Motif’s popular LightSwitch Luciferase Assay System. Each sequence-verified, transfection-ready reporter construct contains the promoter region of a lncRNA gene cloned from the human genome, so you can begin your assays immediately. More >

  • RIME Service: Identify Protein Interactions by Mass Spectrometry

    Adding to our growing list of Epigenetic Services offerings, Active Motif now offers RIME (Rapid Immunoprecipitation Mass spectrometry of Endogenous proteins), which allows for the identification of transcriptional co-factors and chromatin associated proteins. More >

  • Low Cell Number ChIP-Sequencing Services

    New advancements in our ChIP-Seq protocols and pipeline have reduced ChIP-Seq starting material requirements by 1,000 fold! In large contrast to the 10,000,000 cell requirement needed to perform standard ChIP-Seq, Active Motif now offers low cell number ChIP-Seq services, that allow you to perform ChIP-Seq with as few as 10,000 cells. More >

  • ChIP-Seq Validated Antibodies for Pluripotent Stem Cell Markers

    Adding to our growing collection of ChIP-Seq validated antibodies, Active Motif now offers ChIP-Seq validated antibodies specific for Oct4, Sox2, Nanog, KLF5 and TCF7L1/TCF3 stem cell pluripotency factors. More >

  • New Recombinant Nucleosomes for use in Enzymatic Assays and Chromatin Assembly

    Active Motif's Recombinant Nucleosomes offer a more biologically relevant choice of substrate when compared to histone proteins alone or synthetic peptides for use in drug discovery screening, analyzing enzyme kinetics or monitoring changes in histone modifications. Each recombinant nucleosome is comprised of octamers of unmodified core histone proteins (H2A, H2B, H3 and H4) bound by DNA. Biotin-tagged Nucleosomes are also available for pull-down or binding assays. More >

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