Active Motif,
Tools to analyze nuclear function,
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Thousands of promoter & 3´UTR clones!

The LightSwitch™ Luciferase Assay System includes over 30,000 human
promoters & 3´UTRs pre-cloned into transfection-ready reporter vectors.
The system also includes collections of optimized synthetic reporter
elements, stable cell lines and miRNA mimics and inhibitors, making
LightSwitch a complete solution for gene regulation studies.

Find Your Clones
LightSwitch Luciferase Assay System

ChIP-Seq Antibodies

Active Motif now has a ChIP-Seq antibody
validation program, so you can
feel confident that our antibodies
will perform well in ChIP-Sequencing.

See our ChIP-Seq Validated Antibodies
ChIP-Seq Antibodies

Cas9 Antibody (mAb)

Active Motif introduces its new Cas9
antibody for use in monitoring the
targeting efficiency and specificity
of Cas9 endonuclease.

Learn More
Cas9 anbibody (mAb)

Finally! ChIP from FFPE Samples!

Formalin-fixed paraffin-embedded (FFPE) tissue collections
contain a wealth of information, but the conditions used to
prepare them has, until now, prevented their use in ChIP.
ChIP-IT® FFPE is the first and only kit sensitive enough to
obtain ChIP-Seq quality DNA from FFPE tissues.

Learn More
ChIP-IT FFPE

Genome-wide Epigenetic Services

Active Motif offers custom, end-to-end services for genome-wide mapping of protein-DNA interactions. This includes ChIP-Seq, RNA-Seq, DNA Methylation, Interactome Profiling, Histone PTM Quantitation, and ChIP Antibody Validation, to name but a few.

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Custom Epigenetic Services

EpiShear™ Probe Sonicator

The EpiShear™ Probe Sonicator is a compact unit that
is ideal for shearing chromatin for ChIP and DNA
methylation studies. The programmable device gives
you complete control over pulse amplitude and duration,
so you can use your optimized settings every time.

Learn More
EpiShear Probe Sonicator

enChIP: Confirm CRISPR/Cas9 Specificity

New Products for Epigenetics Research

  • enChIP Kit to Confirm CRISPR/Cas9 Specificity

    The enChIP Kit uses the CRISPR/Cas9 system to direct a guide RNA (gRNA) and AM-tagged dCas9 protein to a specific genomic locus for immunoprecipitation. enChIP can be used to identify off-target binding effects. More >

  • Quantify Global Changes in 5-hmC

    The Global 5-hmC Quantification Kit is an ELISA-based assay designed to screen for differences in global 5-hydroxymethylcytosine (5-hmC) levels across samples or treatment conditions. The included DNA standards provide quantitative results that are consistent with mass spectrometry. More >

  • Specific Isolation of Nuclear and Cytoplasmic RNA

    The RNA Subcellular Isolation Kit makes it easier to study low abundance RNA transcripts and to demonstrate the role of lncRNA localization with RNA function by providing an efficient method to isolate nuclear or cytoplasmic RNA fractions without cross-contamination. More >

  • Perform ChIP Without Protein-specific Antibodies

    The Tag-ChIP-IT® Kit makes it easy to perform ChIP with transcription factor sequence variants, mutations or truncations by eliminating the need for protein-specific antibodies. Simply clone your protein sequence with Active Motif's unique AM-tag, specifically designed for use in ChIP, transfect your cells and perform ChIP using an antibody directed against the AM-tag. More >

  • Promoter Reporters Validated Using Pathway-specific Inductions

    The LightSwitch™ Validated Pathway Collections contain promoter reporter constructs that were experimentally validated to show significant activation or repression in response to pathway-specific induction conditions, so they are ideal for studying the key promoters that regulate a variety of different pathways, such as inflammation, hypoxia, DNA damage, heat shock, etc. More >

  • Genome-wide Analysis of 5-Hydroxymethylcytosine (5-hmC)

    Active Motif's Hydroxymethyl Collector™–Seq Kit offers a highly sensitive and specific assay for genome-wide analysis of 5-hydroxymethylcytosine. The assay utilizes our proprietary method to label each 5-hmC residue with a modified glucose for specific enrichment. Enriched DNA is ready for use in Next-Generation Sequencing to determine the localization of 5-hmC within the sample. More >

  • Quantify H3K27ac Levels With Our New Histone ELISA

    Histone H3K27 acetylation is a mark of active enhancers. Active Motif offers the first commercially available ELISA to screen for changes in H3K27ac and to quantify the amount of Histone H3 lysine 27 acetylation using our recombinant histone standard. Click to learn more about the Histone H3 acetyl Lys27 ELISA. More >

  • Reduce the Effects of Technical Variation In Your ChIP

    Active Motif has developed a ChIP Normalization Strategy that can be used to normalize ChIP qPCR and ChIP-Seq data to reduce the effects of technical variation and sample processing bias. This normalization strategy can be applied across samples and antibodies. More >

  • Study the Regulation of lncRNA Promoters

    LightSwitch™ lncRNA Promoter Reporter Vectors make it fast and easy to study the unique regulation of lncRNA promoters using Active Motif’s popular LightSwitch Luciferase Assay System. Each sequence-verified, transfection-ready reporter construct contains the promoter region of a lncRNA gene cloned from the human genome, so you can begin your assays immediately. More >

  • RIME Service: Identify Protein Interactions by Mass Spectrometry

    Adding to our growing list of Epigenetic Services offerings, Active Motif now offers RIME (Rapid Immunoprecipitation Mass spectrometry of Endogenous proteins), which allows for the identification of transcriptional co-factors and chromatin associated proteins. More >

  • Low Cell Number ChIP-Sequencing Services

    New advancements in our ChIP-Seq protocols and pipeline have reduced ChIP-Seq starting material requirements by 1,000 fold! In large contrast to the 10,000,000 cell requirement needed to perform standard ChIP-Seq, Active Motif now offers low cell number ChIP-Seq services, that allow you to perform ChIP-Seq with as few as 10,000 cells. More >

  • ChIP-Seq Validated Antibodies for Pluripotent Stem Cell Markers

    Adding to our growing collection of ChIP-Seq validated antibodies, Active Motif now offers ChIP-Seq validated antibodies specific for Oct4, Sox2, Nanog, KLF5 and TCF7L1/TCF3 stem cell pluripotency factors. More >

  • New Recombinant Nucleosomes for use in Enzymatic Assays and Chromatin Assembly

    Active Motif's Recombinant Nucleosomes offer a more biologically relevant choice of substrate when compared to histone proteins alone or synthetic peptides for use in drug discovery screening, analyzing enzyme kinetics or monitoring changes in histone modifications. Each recombinant nucleosome is comprised of octamers of unmodified core histone proteins (H2A, H2B, H3 and H4) bound by DNA. Biotin-tagged Nucleosomes are also available for pull-down or binding assays. More >

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