Active Motif,
Tools to analyze nuclear function,
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Thousands of promoter & 3´UTR clones!

The LightSwitch™ Luciferase Assay System includes over 30,000 human
promoters & 3´UTRs pre-cloned into transfection-ready reporter vectors.
The system also includes collections of optimized synthetic reporter
elements, stable cell lines and miRNA mimics and inhibitors, making
LightSwitch a complete solution for gene regulation studies.

Find Your Clones
LightSwitch Luciferase Assay System

ChIP-Seq Antibodies

Active Motif now has a ChIP-Seq antibody
validation program, so you can
feel confident that our antibodies
will perform well in ChIP-Sequencing.

See our ChIP-Seq Validated Antibodies
ChIP-Seq Antibodies

Cas9 Antibody (mAb)

Active Motif introduces its new Cas9
antibody for use in monitoring the
targeting efficiency and specificity
of Cas9 endonuclease.

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Cas9 anbibody (mAb)

Finally! ChIP from FFPE Samples!

Formalin-fixed paraffin-embedded (FFPE) tissue collections
contain a wealth of information, but the conditions used to
prepare them has, until now, prevented their use in ChIP.
ChIP-IT® FFPE is the first and only kit sensitive enough to
obtain ChIP-Seq quality DNA from FFPE tissues.

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Genome-wide Epigenetic Services

Active Motif offers custom, end-to-end services for genome-wide mapping of protein-DNA interactions. This includes ChIP-Seq, RNA-Seq, DNA Methylation, Interactome Profiling, Histone PTM Quantitation, and ChIP Antibody Validation, to name but a few.

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Custom Epigenetic Services

EpiShear™ Probe Sonicator

The EpiShear™ Probe Sonicator is a compact unit that
is ideal for shearing chromatin for ChIP and DNA
methylation studies. The programmable device gives
you complete control over pulse amplitude and duration,
so you can use your optimized settings every time.

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EpiShear Probe Sonicator

Next Gen DNA Library Preparation Kit

New Products for Epigenetics Research

  • FFPE Bisulfite Conversion Kit

    The FFPE Bisulfite Conversion Kit is designed for the analysis of DNA methylation profiles in FFPE tissue sections. It offers the advantage of providing optimized reagents throughout the workflow to improve recovery of high quality DNA, minimize degradation and provide greater than 99% conversion efficiency. More >

  • enChIP Kit to Confirm CRISPR/Cas9 Specificity

    The enChIP Kit uses the CRISPR/Cas9 system to direct a guide RNA (gRNA) and AM-tagged dCas9 protein to a specific genomic locus for immunoprecipitation. enChIP can be used to identify off-target binding effects. More >

  • Quantify Global Changes in 5-hmC

    The Global 5-hmC Quantification Kit is an ELISA-based assay designed to screen for differences in global 5-hydroxymethylcytosine (5-hmC) levels across samples or treatment conditions. The included DNA standards provide quantitative results that are consistent with mass spectrometry. More >

  • Specific Isolation of Nuclear and Cytoplasmic RNA

    The RNA Subcellular Isolation Kit makes it easier to study low abundance RNA transcripts and to demonstrate the role of lncRNA localization with RNA function by providing an efficient method to isolate nuclear or cytoplasmic RNA fractions without cross-contamination. More >

  • Perform ChIP Without Protein-specific Antibodies

    The Tag-ChIP-IT® Kit makes it easy to perform ChIP with transcription factor sequence variants, mutations or truncations by eliminating the need for protein-specific antibodies. Simply clone your protein sequence with Active Motif's unique AM-tag, specifically designed for use in ChIP, transfect your cells and perform ChIP using an antibody directed against the AM-tag. More >

  • Promoter Reporters Validated Using Pathway-specific Inductions

    The LightSwitch™ Validated Pathway Collections contain promoter reporter constructs that were experimentally validated to show significant activation or repression in response to pathway-specific induction conditions, so they are ideal for studying the key promoters that regulate a variety of different pathways, such as inflammation, hypoxia, DNA damage, heat shock, etc. More >

  • Reduce the Effects of Technical Variation In Your ChIP

    Active Motif has developed a ChIP Normalization Strategy that can be used to normalize ChIP qPCR and ChIP-Seq data to reduce the effects of technical variation and sample processing bias. This normalization strategy can be applied across samples and antibodies. More >

  • RIME Service: Identify Protein Interactions by Mass Spectrometry

    Adding to our growing list of Epigenetic Services offerings, Active Motif now offers RIME (Rapid Immunoprecipitation Mass spectrometry of Endogenous proteins), which allows for the identification of transcriptional co-factors and chromatin associated proteins. More >

  • Low Cell Number ChIP-Sequencing Services

    New advancements in our ChIP-Seq protocols and pipeline have reduced ChIP-Seq starting material requirements by 1,000 fold! In large contrast to the 10,000,000 cell requirement needed to perform standard ChIP-Seq, Active Motif now offers low cell number ChIP-Seq services, that allow you to perform ChIP-Seq with as few as 10,000 cells. More >

  • New Recombinant Nucleosomes for use in Enzymatic Assays and Chromatin Assembly

    Active Motif's Recombinant Nucleosomes offer a more biologically relevant choice of substrate when compared to histone proteins alone or synthetic peptides for use in drug discovery screening, analyzing enzyme kinetics or monitoring changes in histone modifications. Each recombinant nucleosome is comprised of octamers of unmodified core histone proteins (H2A, H2B, H3 and H4) bound by DNA. Biotin-tagged Nucleosomes are also available for pull-down or binding assays. More >

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