DNA Methylation Products
With kits to enrich for hyper- or hypomethylated DNA,
perform bisulfite conversion, hMeDIP & MeDIP, as well
as 5-hmC, 5-mC & 3-mC antibodies, Active Motif has an
entire suite of products to help study DNA Methylation.
With kits to enrich for hyper- or hypomethylated DNA,
perform bisulfite conversion, hMeDIP & MeDIP, as well
as 5-hmC, 5-mC & 3-mC antibodies, Active Motif has an
entire suite of products to help study DNA Methylation.
Our products to study histones & histone modifications
include MODified™ arrays, Histone Modification ELISAs,
recombinant histones, HAT/HDAC assays and enzymes,
kits for histone purification & chromatin assembly, as well
as over 100 antibodies to specific histone modifications.
Active Motif offers over 570 antibodies
directed against histones, histone
modifications, transcription factors
and other regulatory proteins, many
of which are ChIP validated.
TransAM® Kits are DNA-binding assays that facilitate
the study of transcription factor activation in mammalian
tissue and cell culture extracts. TransAM has
been cited in over 800 papers, making
it the overwhelming method of choice.
Active Motif offers custom research services to facilitate
your studies of transcription factor distribution and function,
histone modifications and DNA methylation. Services include
ChIP, ChIP-on-chip, ChIP-Seq, 5-hmC MeDIP-Seq as well as
bisulfite & next-gen sequencing, to name a few.
RapidReporter® Gaussia Luciferase vectors contain
double destabilizing elements that degrade the basal
luciferase protein AND its mRNA. This reduces background,
while improving response time and sensitivity.
At Active Motif, we develop innovative cell biology-based research tools and biocomputing resources that help researchers elucidate the function, regulation and interactions of the genes and their encoded proteins. Our goal is to provide our customers with high-quality products complemented by superior service & support.
DNA methylation is an important part of mechanisms regulating genome accessibility and function, and Active Motif offers a number of kits and reagents to study the different forms of methylated DNA. In addition to 5-methylcytosine and 5-hydroxymethylcytosine methylation, we now offer highly specific and well validated antibodies for the study of two novel forms of methylation, 5-formylcytosine and 5‑carboxylcytosine.
The new EpiShear™ Multi-Sample Sonicator is a high-intensity cup horn sonicator that can shear up to eight vials (20 µl - 1.2 ml sample per vial) of chromatin or DNA simultaneously for use in chromatin immunoprecipitation (ChIP), DNA methylation studies and Next-Gen sequencing. More >
The new EpiShear™ Cooled Sonication Platform improves sample-to-sample reproducibility when using probe sonicators by keeping the sample cold while enabling the probe to be positioned at the same depth in the sample every time. More >
Active Motif is once again the first company to offer you antibodies for novel DNA modifications. Our new antibodies to 3-Methylcytosine will help you study the function of this form of DNA methylation. More >
Active Motif continues to expand its portfolio of products to study 5-hydroxymethylcytosine. Our new Hydroxymethyl Collector™ Kit is able to chemically label 5-hmC residues for specific enrichment of DNA fragments containing 5-hydroxymethylcytosine. A biotin-streptavidin capture method is used to isolate the labeled 5-hmC residues. More >
To help improve the quality of your sample preparations for chromatin immunoprecipitation experiments or for regular extraction of cell or tissue lysates, Active Motif now offers a Dounce Homogenizer. There are two sizes available for either small or large scale sample preparations. More >
Active Motif has released a number of new antibodies for the study of transcriptional regulation including CtIP, Notch1, PBX, PBX2 and PCL2.
Active Motif offers a large variety of human- and mouse-specific ChIP Control qPCR Primer Sets for many of the more common ChIP targets. These positive and negative controls have been validated and proven to work in both qPCR and endpoint PCR, and are used regularly by our Epigenetics Services division. More >
Active Motif now sells Protease Inhibitor Cocktail. The Protease Inhibitor Cocktail is a combination of six different cysteine, serine, acid and aminopeptidase inhibitors that can be used to protect cell lysates from proteolytic degradation during sample preparation. More >
PvuRts1 I restriction enzyme is the first enzyme capable of directly differentiating between 5-mC and 5-hmC DNA. PvuRts1 I only cleaves 5-hydroxymethylcytosine DNA, in either its glucosylated or non-glucosylated form, while leaving 5-methylcytosine and unmethylated DNA untouched. More >
β-Glucosyltransferase enables modification of 5-hydroxymethylcytosine DNA through the addition of glucose, generating glucosyl-5-hmC DNA. This modified glucosyl-5-hmC DNA can be quantified, or studied using glucosyl-sensitive restriction enzymes. More >
Active Motif now offers a MeDIP Kit for the isolation of single-stranded DNA containing 5-methylcytosine. This kit can be used alone, or in combination with our hMeDIP Kit. More >
To better understand the role of 5-hydroxymethylcytosine (5-hmC) DNA methylation, Active Motif introduces its hMeDIP Kit, which specifically enriches for 5-hmC DNA fragments. Unlike traditional MeDIP, the hMeDIP Kit can be used with double-stranded DNA, which greatly simplifies downstream analysis. More >
Quickly and easily clean up your ChIP DNA with the Chromatin IP DNA Purification Kit. Remove contaminants that interfere with downstream analysis (microarray, qPCR, Next-Gen sequencing). The kit can also prepare DNA for use with our hMeDIP, MethylCollector™ Ultra and UnMethylCollector™ Kits.
Try our new Methylated DNA Standard Kit for experiments examining the different types of DNA methylation. It includes DNA derived from the APC promoter that has no methylation, 5-methylcytosine methylation or 5-hydroxymethylcytosine methylation. Also included are specific primers to aid in detection by PCR.
Active Motif has expanded its line of recombinant histones to include mono-, di- and trimethylated proteins for histone H3 Lys14, Lys18, Lys23 and histone H4 Lys5 and Lys16. We have also added recombinant histone H3 acetyl Lys23. Click here to see a complete listing of the over 40 recombinant methylated and acetylated histones now available.
Screen 384 different histone modification combinations in a single experiment. The MODified™ Histone Peptide Array allows you to screen antibodies or enzymes for interactions with histones and their post-translational modifications on the N-terminal tails of H2A, H2B, H3 and H4. More >
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View recently published, notable papers on epigenetics. More >
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