Active Motif,
Tools to analyze nuclear function,
Your CartYour Cart 0 items

STAY INFORMED

Sign up to receive new product updates
and promotional pricing.

Super-Enhancer Services

specialized ChIP-Seq data generation and analysis

Super-Enhancers are a recently discovered class of regulatory elements that appear to participate in regulating the expression of key genes that function as master regulators of cellular identity. Not surprisingly, misregulation of these critical factors could be an important underlying mechanism in the development of diseases such as cancer. In fact, recent work has focused on the development of drugs that target Super-Enhancers and excitingly, Super-Enhancers near oncogenes are particularly sensitive to treatment and therefore show great promise as therapeutic targets.1,2,3

SE Ab
 
SE signal
 

Antibodies for known Super-Enhancer targets

Super-Enhancer (ChIP-Seq) Service includes:

Customers submit frozen tissues or cell pellets, then we:

  1. Prepare chromatin samples and sonicate.
  2. Perform ChIP with a ChIP-qualified antibody.
  3. Construct ChIP-Seq libraries.
  4. Perform Next-Gen sequencing using an Illumina platform.
  5. Generate a comprehensive data analysis package.
  6. Deliver the results to the customer.

To learn more, please give us a call or send us an Epigenetic Services Information Request. You can also download Active Motif’s Epigenetic Services Profile.

Patent Information:

Patent Number: 9,181,580, Syros Pharmaceuticals

References:

  1. Hnisz et al. (2013) Cell 155, 934
  2. Chapuy et al. (2013) Cancer Cell 24, 777
  3. Loven et al. (2013) Cell 153, 320