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The ErbB-2 proto-oncogene, also called Neu, EGFR-2 or HER-2, is a member of the transmembrane receptor tyrosine kinase family, which also includes EGF receptor and EGFR-3 (HER-3 or ErbB-3). Although, ErbB-2 does not have any known high-affinity ligands, its kinase activity can be activated without ligand by either overexpression or heteroassociation with other members of the ErbB family. Amplification of the ErbB-2 gene and overexpression of its product has been detected in almost 40% of primary human breast tumors, which correlates with poor prognosis in node positive breast cancer. ErbB-2 overexpression is also observed in ovarian, gastric, salivary and non-small cell lung carcinomas. Because of this, ErbB-2 is one of the major drug targets for breast cancer and other cancer treatments.
| Name | Format | Cat. No. | Price | |
|---|---|---|---|---|
| FACE™ ErbB-2 (Y877) | 1 x 96 rxns | 48130 | $ 435 |  |
| FACE™ ErbB-2 (Y877) | 5 x 96 rxns | 48630 | $ 1825 | |
| FACE™ ErbB-2 (Y877) Chemi | 1 x 96 rxns | 48230 | $ 485 | |
| FACE™ ErbB-2 (Y877) Chemi | 5 x 96 rxns | 48730 | $ 2035 | |
| FACE™ ErbB-2 (Y1248) | 1 x 96 rxns | 48105 | $ 435 | |
| FACE™ ErbB-2 (Y1248) | 5 x 96 rxns | 48605 | $ 1825 | |
| FACE™ ErbB-2 (Y1248) Chemi | 1 x 96 rxns | 48205 | $ 485 | |
| FACE™ ErbB-2 (Y1248) Chemi | 5 x 96 rxns | 48705 | $ 2035 | |
