Focal adhesion kinase (FAK) is a widely expressed non-receptor cytoplasmic tyrosine kinase that is implicated in integrin-mediated signal transduction. FAK plays an important role in the control of several biological processes, including cell spreading, migration and survival. Physical interactions of FAK with the integrin cytoplasmic domain and cytoskeletal proteins talin, paxillin and/or tensin play a key role in FAK activation by facilitating its oligomerization and transphosphorylation. FAK shows a rapid increase in tyrosine phosphorylation when stimulated by diverse signaling molecules, including those that regulate embryonic development, cell proliferation, migration and apoptosis, and efficient study methods are in high demand.
YOUR CART
