YOUR CART
AML/Runx factors are essential for blood, skeletal and gastric development and are composed of heterodimeric α and β subunits. In mammals, the α subunits are encoded by three genes, Runx1, 2 and 3, while the β subunit (PEBP2β, CBFβ) is ubiquitously expressed. AML-1/Runx1 is essential for definitive hematopoiesis and is one of the most frequently mutated genes in human leukemia development, while AML-3/Runx2 controls osteoblast differentiation and the development of hypertrophic cartilage. Mutations of AML-3 lead to the rare bone disease cleidocranial dysplasia (CCD) and are associated with human leukemia.
Contents & Storage
One or five 96-well plate(s) with plate sealer(s), primary antibody, HRP-conjugated secondary antibody, wild-type and mutated oligonucleotides, positive control cell extract, DTT, Herring Sperm DNA, Protease Inhibitor Cocktail, Lysis, Binding, 10X Washing and 10X Antibody Binding Buffers, and Developing and Stop Solutions. Reagent storage conditions vary from room temperature to -80°C, see manual for details. All reagents are guaranteed stable for 6 months when stored properly.
