YOUR CART
AP-1 proteins play a role in the expression of many genes involved in cellular proliferation and cell cycle progression. The transcription factor AP-1 is composed of a mixture of heterodimeric protein complexes derived from the Fos and Jun families, including c-Fos, FosB, Fra-1, Fra-2, c-Jun, JunB and JunD. AP-1 heterodimers bind to DNA on a serum response element with the 5´-TGA(C/G)TCA-3´ sequence. Jun proteins can bind to form transcriptionally active homodimers or heterodimers with CREB/ATF members to bind the CRE element. AP-1 expression is induced by multiple stimuli, including the presence of serum, growth factors, phorbol esters and oncogenes. Phosphorylation of AP-1 family members by kinases is required for transactivation activity.
| Name | Format | Cat. No. | Price | |
|---|---|---|---|---|
| TransAM™ AP-1 Family | 2 x 96 rxns | 44296 | $ 995 |  |
| TransAM™ AP-1 c-Fos | 1 x 96 rxns | 44096 | $ 605 | |
| TransAM™ AP-1 c-Fos | 5 x 96 rxns | 44596 | $ 2595 | |
| TransAM™ AP-1 c-Jun | 1 x 96 rxns | 46096 | $ 605 | |
| TransAM™ AP-1 c-Jun | 5 x 96 rxns | 46596 | $ 2595 | |
| TransAM™ AP-1 FosB | 1 x 96 rxns | 45096 | $ 605 | |
| TransAM™ AP-1 FosB | 5 x 96 rxns | 45596 | $ 2595 | |
| TransAM™ AP-1 JunD | 1 x 96 rxns | 43496 | $ 605 | |
| TransAM™ AP-1 JunD | 5 x 96 rxns | 43996 | $ 2595 | |
