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c-Myc is a transcription factor that regulates cell growth and differentiation, glycolysis and apoptosis. Deregulation of c-Myc has been implicated in the origin of diverse human cancers, and may contribute to as much as one-seventh of U.S. cancer deaths. Because of this link between c-Myc and cancer, accurate monitoring of c-Myc in cells, tissues and animals is crucial for many biomedical research and drug development projects. TransAM c-Myc Kits contain an antibody specific for the active form of c-Myc when bound to its target DNA. Because of c-Myc's regulation by MAPK, we also offer the TransAM MAPK Family Kit for studying the MAPK regulated transcription factors ATF-2, c-Jun, c-Myc, MEF2 and STAT1α.
Figure 1: Measurement of c-Myc activity.
Different amounts of nuclear extracts from untreated Jurkat and U-937 cells are tested for c-Myc activity using the TransAM c-Myc Kit.
