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The family of C/EBP (CCAAT-enhancer binding protein) basic leucine zipper transcription factors includes C/EBPα, C/EBPβ, C/EBPδ, C/EBPγ and C/EBPε. Each member exhibits similar DNA-binding specificities and contains a leucine zipper dimerization region. C/EBPs play an important role in regulating the balance between cell growth and differentiation. C/EBP expression is, therefore, a function of tissue type as well as temporal period of development. The TransAM C/EBP α/β Kit contains antibodies specific for the active form of C/EBPα and C/EBPβ when bound to the target DNA.
Figure 1: Specificity of C/EBPβ binding.
Increasing amounts of rat liver nuclear extract are assayed using the TransAM C/EBP α/β Kit in the presence or absence of competitor oligonucleotides containing the wild-type or a mutated form of the C/EBP consensus binding site.
