Cyclic AMP Response Element-Binding (CREB) protein is critical in a variety of cellular processes such as cell proliferation, differentiation and adaptive responses. CREB is a member of a large family of structurally related transcription factors and recognizes the cAMP-response element (CRE) promoter site (5´-TGACGTCA-3´). CREB proteins activate the transcription of target genes in response to a diverse array of stimuli, such as the introduction of peptide hormones or growth factors, and neuronal activity. CREB activation is mediated by a variety of protein kinases, including protein kinase A (PKA), mitogen-activated protein kinases (MAPKs), and Ca+2 calmodulin-dependent protein kinases (CaMKs). These phosphorylate CREB at the Ser133 residue. Both phosphorylation at Ser133 and the binding of coactivator CBP (CREB-binding protein) are required to induce CREB-mediated transcription. TransAM CREB and pCREB Kits contain antibody directed against CREB and phosphorylated CREB, respectively.
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