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Estrogen receptors (ER) are nuclear receptors that mediate the actions of the endogenous steroid hormone, 17β-estradiol (E2). ER is synthesized as two protein forms, ERα and ERβ, which can bind to the estrogen receptor element (ERE) as homo- or heterodimers. Cell proliferation and differentiation triggered by ER activation has been heavily studied in bone-wasting and breast cancer treatments. The TransAM ER Kit contains an antibody specific for the active form of ERα when it is bound to the target DNA.
Contents & Storage
One or five ER 96-well plate(s) with plate sealer(s), ERα primary antibody, HRP-conjugated secondary antibody, ER wild-type and mutated oligonucleotides, positive control cell extract, Dithiothreitol, Protease Inhibitor Cocktail, Lysis, Binding, 10X Washing and 10X Antibody Binding Buffers, Developing and Stop Solutions and Poly[d(I-C)]. Reagent storage conditions vary from room temperature to -80°C, see manual for details. All reagents are guaranteed stable for 6 months.
