YOUR CART
The Forkhead transcription factor FKHR (FOXO1) regulates expression of gluconeogenic factors and plays a key role in insulin regulation of glucose levels. Besides its role in glucose homeostasis, FKHR has been shown to be involved in pathological processes such as type 2 diabetes, cancer and organismal aging. The transcriptional output of FKHR is controlled by a two-tiered mechanism of phosphorylation and acetylation, and alterations in this balance can result in profound effects.
Figure 1: Monitoring FKHR activity with the TransAM FKHR Kit.
Different amounts of nuclear extracts from untreated Raji (purple bars) and HeLa (copper bars) cells are tested for FKHR activity using the TransAM FKHR Kit.
