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The transcription factor known as Nuclear Factor of Activated T cells (NFAT) binds to several sites within the regulatory region of the IL-2 gene and other genes induced during the immune response. Because its activation is inhibited by the main immunosuppressive drugs in current clinical use, cyclosporin A and tacrolimus (FK506), accurate monitoring of NFAT activation in cells, tissues and animals is crucial for biomedical research and drug development.
Contents & Storage
One or five NFAT 96-well assay plate(s) with plate sealer(s), NFATc1 primary antibody, HRP-conjugated secondary antibody, NFAT wild-type and mutated oligonucleotides, Jurkat nuclear extract (positive control), Dithiothreitol, Protease Inhibitor Cocktail, poly[d(I-C)], Lysis, Binding, 10X Washing and 10X Antibody Binding Buffers, and Developing and Stop Solutions. Reagent storage conditions vary from room temperature to -80°C, see manual for details. All reagents are guaranteed stable for 6 months when stored properly.
