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The transcription factor known as Nuclear Factor of Activated T cells (NFAT) binds to several sites within the regulatory region of the IL-2 gene and other genes induced during the immune response. Because its activation is inhibited by the main immunosuppressive drugs in current clinical use, cyclosporin A and tacrolimus (FK506), accurate monitoring of NFAT activation in cells, tissues and animals is crucial for biomedical research and drug development.
Applications
- NFATc1-mediated transcriptional regulation
- Protein structure/function studies of NFATc1, NFATc1 cytoplasmic/nuclear shuttling
- NFATc1 antagonist drug validation in areas such as immune response, angiogenesis, myogenesis, and many more
Figure 1: Monitoring NFATc1 activation with the TransAM NFATc1 Kit.
Different amounts of nuclear extract from untreated Raji and HeLa cells are tested for NFATc1 activation using the TransAM NFATc1 Kit.
