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Oct-4 (Oct-3/4, POU5F1) is a key factor involved in the first differentiation step of embryogenesis and functions to maintain an undifferentiated cell state. Because of the importance of Oct-4 in normal development, accurate monitoring of Oct-4 in cells, tissues, and animals is crucial for many biomedical research and drug development projects.
Applications
- Drug screening and/or potency studies
- Studies of Oct-4 transcriptional activity regulation
- Protein structure/function studies of Oct-4
Figure 1: Monitoring Oct-4 activation with the TransAM Oct-4 Kit.
Different amounts of nuclear extracts from unstimulated P19 and HeLa cells are tested for Oct-4 activation using the TransAM Oct-4 Kit.
