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The p53 tumor suppressor is a transcription factor that controls the expression of many genes implicated in cell growth control, DNA repair, cell-cycle arrest, apoptosis, angiogenesis, redox regulation, metastasis, nitric oxide production and protein degradation. p53 transactivation is regulated by phosphorylation and interaction with an inhibitory protein, MDM2. Mutational inactivation of the p53 gene product is one of the most common genetic events that occur in human cancers. TransAM p53 contains an antibody specific for the active form of p53 when it is bound to the target DNA.
Contents & Storage
One or five p53 96-well assay plate(s) with plate sealer(s), p53 primary antibody, HRP-conjugated secondary antibody, p53 wild-type and mutated oligonucleotides, MCF-7 nuclear extract (positive control), Dithiothreitol, Protease Inhibitor Cocktail, poly[d(I-C)], Lysis, Binding, 10X Washing and 10X Antibody Binding Buffers, and Developing and Stop Solutions. Reagent storage conditions vary from room temperature to –80°C, see manual for details. All reagents are guaranteed stable for 6 months when stored properly.
