YOUR CART
STATs (signal transducers and activators of transcription) are a family of latent cytoplasmic proteins that are activated when cells encounter various extracellular polypeptides, such as interferons and interleukines. STATs are involved in many pathways that regulate cellular functions in the lympho-hematopoietic system. The STAT family has seven members: STAT1, 2, 3, 4, 5A, 5B and 6. STAT1 forms heterodimers with STAT2 and 3; STAT4 and 5 only form homodimers. Tyrosine phosphorylation around residue 700 is essential for the dimerization of STATs and the concomitant nuclear translocation of the dimer. STAT dimers and heterodimers, but not monomers, are competent to bind DNA.
Contents & Storage
One, two or five STAT 96-well assay plate(s) with plate sealer(s), STAT3 or STAT1α, STAT3, STAT5A and STAT5B primary antibodies, HRP-conjugated secondary antibody, STAT wild-type and mutated oligonucleotides, positive control cell extract, DTT, Protease Inhibitor Cocktail, Lysis, Binding, 10X Washing and 10X Antibody Binding Buffers, and Developing and Stop Solutions. Reagent storage conditions vary from room temperature to -80°C, see manual for details. All reagents are guaranteed stable for 6 months when stored properly.
