		Transcriptional Regulation Co-Immunoprecipitation DNA Repair Luciferase Reporter Assay Nuclear Receptor ELISAs Supershift & Gelshift Assays Transcription Factor ELISA Epigenetics & Chromatin Chromatin Assembly Chromatin IP DNA Damage – Phospho-H2AX DNA Methylation Histone Acetyltransferase Activity (HAT) Histone Deacetylase Activity (HDAC) Histone Modification ELISAs Histone Purification Methylated Histones Protein Modification GTPase Activation Assay Kinase Assay Substrate Mitosis Assays Nitric Oxide Quantitation Phospho-Protein Detection Sandwich ELISAs SUMOylation Antibodies, Extracts & Proteins Antibodies Cell Extracts Recombinant Proteins Fluorescence & Labeling Albumin Quantification Cell Viability Assay Fluorescent Dyes & Labeling Immunofluorescence Live Cell Membrane Staining Mitosis Determination Protein and Extract Quantification Protein Labeling & Translocation Sample Preparation Fluorescent Dye Labeling Mitochondrial Separation mRNA Isolation Normalization Nuclear & Cytoplasmic Extraction Protein & Extract Quantification Transfection & Expression Competent E. coli Gene Silencing Protein Transfection Staining Reagents Bioinformatics & Text Mining TimeLogic® Biocomputing Solutions AKS 2

TransAM™ STAT3 & STAT Family Kits

simplified study of STAT1α, STAT3, STAT5A and STAT5B

STATs (signal transducers and activators of transcription) are a family of latent cytoplasmic proteins that are activated when cells encounter various extracellular polypeptides, such as interferons and interleukines. STATs are involved in many pathways that regulate cellular functions in the lympho-hematopoietic system. The STAT family has seven members: STAT1, 2, 3, 4, 5A, 5B and 6. STAT1 forms heterodimers with STAT2 and 3; STAT4 and 5 only form homodimers. Tyrosine phosphorylation around residue 700 is essential for the dimerization of STATs and the concomitant nuclear translocation of the dimer. STAT dimers and heterodimers, but not monomers, are competent to bind DNA.