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Transcriptional Regulation

GTBP DNA Repair Protein ELISA

 

The G/T binding protein (GTBP, also called MSH6) is a mismatch repair protein that binds as a heterodimer to DNA. GTBP specifically recognizes mismatched G/T base pairs in double-stranded DNA where it triggers excision and repair. Deficiencies in the repair of mismatched G/T base pairs can lead to microsatellite instability and is also linked to hereditary nonpolyposis colon cancer (HNPCC).

 

Contents & Storage

One or five 96-well assay plates with plate sealers, primary antibody, secondary antibody, G/T mismatched and non-mismatched oligonucleotides, positive control cell extract, DTT, Protease Inhibitor Cocktail, Lysis, Binding, 10X Washing and 10X Antibody Binding Buffer, and Developing and Stop Solutions. Reagent storage conditions vary from room temperature to -80°C, see manual for details. All reagents are guaranteed stable for 6 months when stored properly.