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The G/T binding protein (GTBP, also called MSH6) is a mismatch repair protein that binds as a heterodimer to DNA. GTBP specifically recognizes mismatched G/T base pairs in double-stranded DNA where it triggers excision and repair. Deficiencies in the repair of mismatched G/T base pairs can lead to microsatellite instability and is also linked to hereditary nonpolyposis colon cancer (HNPCC).
Applications
GTBP is involved in the maintenance of genomic stability, and therefore represents an excellent pharmacological target for developing drugs to treat cancer. Applications of the GTBP DNA Repair Kit include:
- Profiling of GTBP under various growth and stimulation conditions
- Drug screening and/or potency toward GTBP
- GTBP activity regulation
- Protein structure/function studies of GTBP
Figure 1: Monitoring GTBP binding with the GTBP DNA Repair Kit.
Different amounts of nuclear extracts from unstimulated Raji and Jurkat cells are tested for activity using the GTBP DNA Repair Kit. These curves are provided for demonstration only.
