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ERα is a well-established marker of breast cancer hormone sensitivity, and the quantification of estrogen receptors in breast tumors has been routinely performed in clinical laboratories to aid in the selection between hormonal and chemotherapy and also to predict prognosis. Because of ERα's critical role in cell biology, it is important to measure the total amounts of ERα contained in different cell types and tissues.
Figure 1:Measuring cellular ERα levels.
Different amounts of nuclear extracts from MCF-7 and MDA-MB-231 cells were analyzed for cellular levels of ERα using the NR Sandwich ERα Kit.
Applications
The NR Sandwich ERα has many applications including:
- Study of ER transcriptional activity regulation
- Protein structure/function studies of ER and its mutated variants in areas such as osteoporosis, arteriosclerosis and breast cancer
