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Transcriptional Regulation

TransAM™ Nrf2

 

NF-E2-related factor, Nrf2, is a critical transcription factor in oxidative stress signaling. Nrf2 is a basic leucine zipper transcription factor that binds to the antioxidant responsive element (ARE) and may serve as a master regulator in cellular defense pathways in protecting a wide variety of tissues from various toxic exposure.

TransAM™ Nrf2 is a simple solution for studying Nrf2 activation in human, mouse and rat model systems.

 
 
 
Figure 1: Monitoring Nrf2 activation with the TransAM Nrf2 Kit.

Different amounts of nuclear extracts from Nrf2-transfected (black bars) and mock-transfected (gray bars) COS-7 cells were tested for Nrf2 activation using the TransAM Nrf2 Kit.