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Active Motif offers several products to study cellular structure using fluorescence microscopy or high-content applications. Our Cell and Organelle Stains are a collection of innovative fluorescent dyes that provide specific and efficient staining of subcellular structures in live and in fixed cells. A key feature is that the dyes become fluorescent only after specific binding to target structures; this eliminates background fluorescence caused by any unbound dye. The Cell and Organelle Stains serve as counter-stains in microscopy, and can be used as a live cell stain to monitor changes in cell morphology, changes to mitochondrial structure and number, or as a cell-tracer in cell populations.
- LavaCell™ is a naturally fluorescent compound that diffuses into live or fixed cells, where it stains the plasma membrane and internal membranes, such as those of the nucleus, Golgi and ER.
- Chromeo™ Live Cell Mitochondrial Staining Kit is a membrane permeable dye that selectively stains mitochondria in living cells.
- Chromeo™ Red Fluorescent Fixed Cell Staining Kit serves as a counterstain in immunofluorescence experiments where the red color can be used together with green dyes such as FITC or other 488-excitable dyes.
The following table summarizes the fluorescent properties of the organelle-specific dyes, and provides an overview about their performance in different staining experiments.
| Cell and Organelle Stain | Live cells | Fixed cells | Long-term staining |
Excitation | Emission |
|---|---|---|---|---|---|
| LavaCell™ Live Cell Membrane Staining | ✓ | ✓ | ✓* | 405, 488 and 532 nm | 610 nm |
| Chromeo™ Live Cell Mitochondrial Stain | ✓ | ✓ | ✓ | 470-550 nm | 610 nm |
| Chromeo™ Red Fluorescent Fixed Cell Staining Kit | – | ✓ | – | 520-550 nm | 627 nm |
| * While LavaCell is an excellent tool for long-term studies, the dye needs to be kept in the culture medium during the experiment. | |||||
