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Recombinant Proteins & Enzymes

Histone Methyltransferases (HMTs) and Histone Demethylases (HDMs)

active, recombinant HMT and HDM proteins

Histone methyltransferases (HMT) are histone-modifying enzymes that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues on histone proteins. Methylation of arginine residues is catalyzed by protein arginine methyltransferases (PRMTs) while histone methyltransferases (HMTs) are responsible for lysine methylation. The removal of these histone marks from arginine and lysine residues is catalyzed by protein arginine demethylase (PRDM) and lysine demethylase (KDM) enzymes, respectively.

The methylation of histones is an important post-translational modification that is involved in regulating genome compaction and gene expression. Depending on the amino acid target, methylation can lead to either transcriptional repression or activation.

Active Motif offers a large number of active, recombinant HMT and HDM proteins available in small scale and bulk quantities.

 
Name Expressed In Format Cat No. Price  
Recombinant Carm1 / Prmt4 protein Baculovirus 20 µg 31347 $390 Buy Now
Recombinant Carm1 E267Q protein Baculovirus 10 µg 31348 $390 Buy Now
Recombinant DOT1L (1-416) protein E. coli 50 µg 31474 $395 Buy Now
Recombinant EZH1 Complex Baculovirus 20 µg 31500 $405 Buy Now
Recombinant EZH2 protein complex Baculovirus 25 µg 31337 $395 Buy Now
Recombinant FBXL10 / KDM2B protein Baculovirus 20 µg 31455 $395 Buy Now
Recombinant G9a protein Baculovirus 20 μg 31410 $395 Buy Now
Recombinant G9a protein E. coli 10 µg 31327 $390 Buy Now
Recombinant G9a H904K protein E. coli 10 µg 31328 $390 Buy Now
Recombinant G9a-SET protein E. coli 20 μg 31425 $395 Buy Now
Recombinant JARID1A / KDM5A protein Baculovirus 20 μg 31431 $395 Buy Now
Recombinant JARID1B / KDM5B protein Sf9 cells 20 μg 31432 $395 Buy Now
Recombinant JARID1C / KDM5C protein Baculovirus 20 μg 31433 $395 Buy Now
Recombinant JHDM1D-l protein E. coli 20 µg 31464 $415 Buy Now
Recombinant JHDM1D-s protein E. coli 20 µg 31463 $415 Buy Now
Recombinant JMJD1A / KDM3A protein Baculovirus 20 µg 31456 $395 Buy Now
Recombinant JMJD1B / KDM3B protein Baculovirus 20 μg 31429 $395 Buy Now
Recombinant JMJD2A / KDM4A protein Baculovirus 20 µg 31457 $395 Buy Now
Recombinant JMJD2B / KDM4B protein Baculovirus 20 µg 31501 $395 Buy Now
Recombinant JMJD2C / KDM4C protein Baculovirus 20 µg 31458 $395 Buy Now
Recombinant JMJD2D / KDM4D protein Baculovirus 20 µg 31459 $395 Buy Now
Recombinant KDM1B / LSD2 protein Baculovirus 20 µg 31479 $395 Buy Now
Recombinant KDM2A / FBXL11 protein Baculovirus 20 µg 31485 $395 Buy Now
Recombinant LSD1 / KDM1A protein Baculovirus 20 μg 31426 $395 Buy Now
Recombinant LSD1 / KDM1A protein E. coli 50 µg 31507 $395 Buy Now
Recombinant MLL / HRX - SET protein E. coli 20 μg 31419 $395 Buy Now
Recombinant MLL1 Complex Baculovirus 20 µg 31423 $405 Buy Now
Recombinant MLL2 Complex E. coli 20 µg 31498 $405 Buy Now
Recombinant MLL2-SET protein E. coli 20 μg 31420 $395 Buy Now
Recombinant MLL3 Complex E. coli 20 µg 31478 $395 Buy Now
Recombinant MLL4 Complex E. coli 20 µg 31499 $405 Buy Now
Recombinant MLL4-SET protein E. coli 20 μg 31422 $395 Buy Now
Recombinant MMSET / WHSC1 protein Baculovirus 20 µg 31453 $395 Buy Now
Recombinant MMSET / WHSC1 - SET protein E. coli 50 µg 31476 $395 Buy Now
Recombinant NSD1-SET protein E. coli 50 µg 31475 $395 Buy Now
Recombinant PHF8 protein Baculovirus 20 μg 31435 $395 Buy Now
Recombinant PHF8-l protein E. coli 20 µg 31462 $415 Buy Now
Recombinant PHF8-s protein E. coli 20 µg 31461 $415 Buy Now
Recombinant PRC2 Complex Baculovirus 20 µg 31387 $415 Buy Now
Recombinant PRC2 EZH2(Y641C) Complex Baculovirus 20 µg 31389 $415 Buy Now
Recombinant PRC2 EZH2(Y641F) Complex Baculovirus 20 µg 31388 $415 Buy Now
Recombinant PRC2 EZH2(Y641N) Complex Baculovirus 20 µg 31390 $415 Buy Now
Recombinant PRC2 EZH2(A677G) Complex Baculovirus 20 µg 31391 $415 Buy Now
Recombinant PRDM6 protein Baculovirus 20 µg 31495 $395 Buy Now
Recombinant PRDM9 (191-414) protein E. coli 20 µg 31510 $395 Buy Now
Recombinant PRDM10 protein Baculovirus 20 µg 31396 $415 Buy Now
Recombinant PRDM14 protein Baculovirus 20 µg 31397 $415 Buy Now
Recombinant PRMT1 protein Baculovirus 20 μg 31411 $395 Buy Now
Recombinant PRMT1 protein E. coli 10 µg 31325 $390 Buy Now
Recombinant PRMT1 E143Q protein E. coli 10 µg 31326 $390 Buy Now
Recombinant PRMT2 protein Baculovirus 20 µg 31392 $415 Buy Now
Recombinant PRMT3 protein Baculovirus 20 μg 31412 $395 Buy Now
Recombinant PRMT5 protein Baculovirus 20 µg 31393 $415 Buy Now
Recombinant PRMT5 complex Baculovirus 20 µg 31356 $390 Buy Now
Recombinant PRMT6 protein Baculovirus 20 µg 31394 $415 Buy Now
Recombinant PRMT7 protein Baculovirus 20 µg 31395 $395 Buy Now
Recombinant RIZ1 protein E. coli 200 µg 31357 $390 Buy Now
Recombinant Set2 protein E. coli 50 µg 31358 $390 Buy Now
Recombinant Set8 protein E. coli 10 µg 31321 $390 Buy Now
Recombinant Set8 D338A protein E. coli 10 µg 31322 $390 Buy Now
Recombinant Set9 protein E. coli 10 µg 31319 $390 Buy Now
Recombinant Set9 H297A protein E. coli 10 µg 31320 $390 Buy Now
Recombinant SETD2 (1392-2564) protein Baculovirus 20 µg 31399 $415 Buy Now
Recombinant SETD7 protein Baculovirus 20 µg 31496 $395 Buy Now
Recombinant SETD8 protein Baculovirus 20 µg 31427 $395 Buy Now
Recombinant SETDB1 protein Baculovirus 20 µg 31452 $415 Buy Now
Recombinant SETMAR protein Baculovirus 20 µg 31454 $395 Buy Now
Recombinant SMYD1 protein Baculovirus 20 μg 31405 $415 Buy Now
Recombinant SMYD2 protein Baculovirus 20 µg 31497 $395 Buy Now
Recombinant Smyd2 protein E. coli 10 µg 31323 $390 Buy Now
Recombinant Smyd2 Y240F protein E. coli 10 µg 31324 $390 Buy Now
Recombinant SMYD3 protein Baculovirus 20 μg 31407 $395 Buy Now
Recombinant SMYD4 protein Baculovirus 20 μg 31408 $395 Buy Now
Recombinant SMYD5 protein Baculovirus 20 μg 31409 $395 Buy Now
Recombinant SUV39H1 protein E. coli 25 µg 31339 $390 Buy Now
Recombinant SUV39H2 protein E. coli 50 µg 31359 $390 Buy Now
Recombinant SUV420H1 protein E. coli 50 µg 31360 $390 Buy Now
Recombinant SUV420H2 protein E. coli 50 µg 31361 $390 Buy Now
Recombinant UTX / KDM6A protein Baculovirus 20 µg 31460 $395 Buy Now
Recombinant vSET protein E. coli 5 µg 31402 $380 Buy Now
Recombinant WHSC1L1 / NSD3 - SET protein E. coli 50 µg 31477 $395 Buy Now