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Recombinant Proteins & Enzymes

Histone Methyltransferases (HMTs) and Histone Demethylases (HDMs)

active, recombinant HMT and HDM proteins

Histone methyltransferases (HMT) are histone-modifying enzymes that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues on histone proteins. Methylation of arginine residues is catalyzed by protein arginine methyltransferases (PRMTs) while histone methyltransferases (HMTs) are responsible for lysine methylation. The removal of these histone marks from arginine and lysine residues is catalyzed by protein arginine demethylase (PRDM) and lysine demethylase (KDM) enzymes, respectively.

The methylation of histones is an important post-translational modification that is involved in regulating genome compaction and gene expression. Depending on the amino acid target, methylation can lead to either transcriptional repression or activation.

Active Motif offers a large number of active, recombinant HMT and HDM proteins available in small scale and bulk quantities.

 
Name Expressed In Format Cat No. Price  
Recombinant DOT1L (1-416) protein E. coli 50 µg 31474 $405 Buy Now
1 mg 31874 $2,900 Buy Now
Recombinant EHMT1 (894-1298) protein E. coli 50 µg 31520 $405 Buy Now
1 mg 31920 $2,900 Buy Now
Recombinant EHMT2 (G9a) protein Baculovirus 20 μg 31410 $405 Buy Now
1 mg 31810 $3,500 Buy Now
Recombinant EHMT2-SET (G9a) protein E. coli 50 µg 31425 $405 Buy Now
1 mg 31825 $2,900 Buy Now
Recombinant EZH1 complex Baculovirus 20 µg 31500 $420 Buy Now
1 mg 31904 $3,800 Buy Now
Recombinant EZH2 protein complex Baculovirus 25 µg 31337 $405 Buy Now
Recombinant FBXL10 / KDM2B protein Baculovirus 20 µg 31455 $405 Buy Now
Recombinant JARID1A / KDM5A protein Baculovirus 20 μg 31431 $405 Buy Now
1 mg 31831 $3,800 Buy Now
Recombinant JARID1B / KDM5B protein Sf9 cells 20 μg 31432 $405 Buy Now
1 mg 31832 $3,800 Buy Now
Recombinant JARID1B / KDM5B (2-751) protein Baculovirus 20 µg 31518 $405 Buy Now
Recombinant JARID1C / KDM5C protein Baculovirus 20 μg 31433 $405 Buy Now
1 mg 31833 $3,800 Buy Now
Recombinant JHDM1D-l protein E. coli 20 µg 31464 $425 Buy Now
Recombinant JHDM1D-s protein E. coli 20 µg 31463 N/A
Recombinant JMJD1A / KDM3A protein Baculovirus 20 µg 31456 $405 Buy Now
Recombinant JMJD1B / KDM3B protein Baculovirus 20 μg 31429 $405 Buy Now
Recombinant JMJD2A / KDM4A protein Baculovirus 20 µg 31457 $405 Buy Now
1 mg 31857 $3,500 Buy Now
Recombinant JMJD2B / KDM4B protein Baculovirus 20 µg 31501 $405 Buy Now
Recombinant JMJD2C / KDM4C protein Baculovirus 20 µg 31458 $405 Buy Now
1 mg 31858 $3,500 Buy Now
Recombinant JMJD2D / KDM4D protein Baculovirus 20 µg 31459 $405 Buy Now
Recombinant JMJD3 / KDM6B (1043-1682) protein Baculovirus 20 µg 31519 $405 Buy Now
1 mg 31919 $3,500 Buy Now
Recombinant KDM1B / LSD2 protein Baculovirus 20 µg 31479 $405 Buy Now
1 mg 31879 $3,500 Buy Now
Recombinant KDM2A / FBXL11 protein Baculovirus 20 µg 31485 $405 Buy Now
Recombinant KDM6C protein Baculovirus 10 µg 31575 $405 Buy Now
Recombinant KDM7A protein Baculovirus 10 µg 31576 $405 Buy Now
Recombinant KMT2A (MLL1) protein E. coli 50 µg 31419 $405 Buy Now
1 mg 31819 $3,200 Buy Now
Recombinant KMT2A (MLL1) complex E. coli 20 µg 31423 $425 Buy Now
1 mg 31823 $3,500 Buy Now
Recombinant KMT2B (MLL2) protein E. coli 20 μg 31420 $405 Buy Now
1 mg 31820 $3,200 Buy Now
Recombinant KMT2B (MLL2) complex E. coli 20 µg 31498 $420 Buy Now
1 mg 31902 $3,500 Buy Now
Recombinant KMT2C (MLL3) complex E. coli 20 µg 31478 $405 Buy Now
1 mg 31878 $3,500 Buy Now
Recombinant MLL4-SET protein E. coli 50 µg 31422 $405 Buy Now
1 mg 31822 $3,200 Buy Now
Recombinant KMT2D (MLL4) complex E. coli 20 µg 31499 $420 Buy Now
1 mg 31903 $3,500 Buy Now
Recombinant LSD1 / KDM1A protein E. coli 50 µg 31507 $405 Buy Now
Recombinant LSD1 / KDM1A protein Baculovirus 20 μg 31426 $405 Buy Now
1 mg 31826 $3,500 Buy Now
Recombinant NSD1-SET protein E. coli 50 µg 31475 $405 Buy Now
1 mg 31775 $3,500 Buy Now
Recombinant NSD2 (MMSET) protein Baculovirus 20 µg 31453 $405 Buy Now
1 mg 31853 $3,800 Buy Now
Recombinant NSD2-SET (MMSET) protein E. coli 50 µg 31476 $405 Buy Now
1 mg 31776 $3,500 Buy Now
Recombinant NSD2 (E1099K) protein Baculovirus 20 µg 31546 $405 Buy Now
Recombinant NSD2-SET (E1099K) protein E. coli 50 µg 31574 $405 Buy Now
1 mg 31974 $3,500 Buy Now
Recombinant NSD3 (WHSC1L1) protein E. coli 50 µg 31477 $405 Buy Now
1 mg 31877 $3,500 Buy Now
Recombinant PHF8 protein Baculovirus 20 μg 31435 $405 Buy Now
Recombinant PHF8-l protein E. coli 20 µg 31462 N/A
Recombinant PHF8-s protein E. coli 20 µg 31461 N/A
Recombinant PRC2 complex Baculovirus 20 µg 31387 $425 Buy Now
1 mg 31887 $3,800 Buy Now
Recombinant PRC2 EZH2(Y641C) complex Baculovirus 20 µg 31389 $425 Buy Now
1 mg 31789 $3,800 Buy Now
Recombinant PRC2 EZH2(Y641F) complex Baculovirus 20 µg 31388 $425 Buy Now
1 mg 31888 $3,800 Buy Now
Recombinant PRC2 EZH2(Y641N) complex Baculovirus 20 µg 31390 $425 Buy Now
1 mg 31790 $3,800 Buy Now
Recombinant PRC2 EZH2 (A677G) complex Baculovirus 20 µg 31391 $425 Buy Now
1 mg 31891 $3,800 Buy Now
Recombinant PRDM6 protein Baculovirus 20 µg 31495 $405 Buy Now
Recombinant PRDM9 (191-414) protein E. coli 20 µg 31510 $405 Buy Now
Recombinant PRDM10 protein Baculovirus 20 µg 31396 $425 Buy Now
Recombinant PRDM14 protein Baculovirus 20 µg 31397 $425 Buy Now
Recombinant PRMT1 protein Baculovirus 20 μg 31411 $405 Buy Now
Recombinant PRMT2 protein Baculovirus 20 µg 31392 $425 Buy Now
Recombinant PRMT3 protein Baculovirus 20 μg 31412 $405 Buy Now
Recombinant PRMT6 protein Baculovirus 20 µg 31394 $425 Buy Now
Recombinant PRMT7 protein Baculovirus 20 µg 31395 $425 Buy Now
Recombinant RIZ1 protein E. coli 200 µg 31357 N/A
Recombinant vSET protein E. coli 5 µg 31402 $405 Buy Now
Recombinant SET2 protein E. coli 50 µg 31358 $405 Buy Now
Recombinant SETD7 protein Baculovirus 20 µg 31496 $405 Buy Now
Recombinant SETD8 protein Baculovirus 20 µg 31427 $405 Buy Now
Recombinant SETD2 (1392-2564) protein Baculovirus 20 µg 31399 $425 Buy Now
Recombinant SETDB1 protein Baculovirus 20 µg 31452 $425 Buy Now
Recombinant SETMAR protein Baculovirus 20 µg 31454 $405 Buy Now
Recombinant SMYD1 protein Baculovirus 20 μg 31405 $425 Buy Now
1 mg 31805 $3,800 Buy Now
Recombinant SMYD2 protein Baculovirus 20 µg 31497 $405 Buy Now
Recombinant SMYD3 protein Baculovirus 20 μg 31407 $405 Buy Now
Recombinant SMYD4 protein Baculovirus 20 μg 31408 $405 Buy Now
Recombinant SMYD5 protein Baculovirus 20 μg 31409 $405 Buy Now
Recombinant SUV39H1 protein E. coli 25 µg 31339 N/A
Recombinant SUV39H2 (26-350) protein E. coli 50 µg 31359 N/A
Recombinant SUV420H1 protein E. coli 50 µg 31360 N/A
Recombinant UTX / KDM6A protein Baculovirus 20 µg 31460 $405 Buy Now