Active Motif,
Tools to analyze nuclear function,
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Epigenetics & Chromatin

Histone Methylation (HMT & HDM)

epigenetic modulators of HMTs & HDMs

Histone methylation is a reversible reaction that occurs on lysine or arginine residues of histone tails. Histone methyltransferases (HMTs) catalyze the transfer of a methyl group, while histone demethylases (HDMs) perform the antagonistic action of removing the methyl group. Lysine residues can be mono-, di- or tri-methylated and arginine residues can undergo asymmetric or symmetric dimethylation. Histone methylation plays an important role in transcriptional regulation.

Active Motif offers several small molecules to study the effect of changes in HMT and HDM activity.

 
Name Application Format Cat No. Price  
AS-8351 KDM5B lysine demethylase inhibitor 25 mg 14112 $275 Buy Now
5 mg 14113 $65 Buy Now
BIX-01294 G9a/GLP HMT inhibitor 25 mg 14072 $475 Buy Now
5 mg 14073 $145 Buy Now
Chaetocin SU(VAR)3-9 methyltransferase inhibitor 200 µg 14051 $85 Buy Now
Daminozide KDM2/KDM7 HDM inhibitor 250 mg 14058 $140 Buy Now
50 mg 14059 $45 Buy Now
DMOG PHD/JMJD2A inhibitor 50 mg 14062 $295 Buy Now
10 mg 14063 $75 Buy Now
GSK-J1 (cell impermeable) JMJD3/UTX inhibitor 25 mg 14068 $330 Buy Now
5 mg 14069 $85 Buy Now
GSK-J4 (cell permeable) JMJD3/UTX inhibitor 25 mg 14070 $330 Buy Now
5 mg 14071 $85 Buy Now
IOX1 JMJD family inhibitor 25 mg 14056 $345 Buy Now
5 mg 14057 $90 Buy Now
ML-324 JMJD2 HDM inhibitor 25 mg 14078 $370 Buy Now
5 mg 14079 $95 Buy Now
NSC-663284 SETD8 KMT inhibitor 25 mg 14122 $375 Buy Now
5 mg 14123 $95 Buy Now
PBIT JARID1 inhibitor 25 mg 14110 $235 Buy Now
5 mg 14111 $65 Buy Now
Tranylcypromine hemisulfate LSD1/BHC110 inhibitor 250 mg 14046 $155 Buy Now
50 mg 14047 $50 Buy Now
UNC1999 EZH1 & EZH2 lysine methyltransferase inhibitor 25 mg 14114 $325 Buy Now
5 mg 14115 $110 Buy Now
UNC-2170 Methyl-lysine Binding Protein Inhibitor 25 mg 14120 $450 Buy Now
5 mg 14121 $110 Buy Now