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Epigenetics & Chromatin

Sirtuins (SIRT & Sir2)

epigenetic modulators of sirtuins

Sirtuins are NAD-dependent deacetylases that are highly conserved among species. The original family member, Sir2 (silent mating-type information regulator 2) from yeast was identified as a gene involved in maintaining silent chromatin. In mammals, there are seven sirtuins (SIRT1-7) belonging to the class III histone deacetylase (HDAC) family of proteins. These are the only HDACs that require NAD for their enzymatic activity. Sirtuins play a role in metabolic diseases, neuronal physiology and aging, making them an important area of research.

Active Motif offers several activators and inhibitors to study the effects of Sirtuins.

 
Name Appl. Format Cat No. Price  
AK-7 SIRT2 Inhibitor 25 mg 14054 $275 Buy Now
5 mg 14055 $80 Buy Now
BML-278 SIRT1 Activator 25 mg 14024 $295 Buy Now
5 mg 14025 $85 Buy Now
EX-527 SIRT1 Inhibitor 25 mg 14028 $335 Buy Now
5 mg 14029 $90 Buy Now
Piceatannol SIRT1 Activator 25 mg 14036 $240 Buy Now
5 mg 14037 $70 Buy Now
Resveratrol SIRT1 Activator 500 mg 14022 $240 Buy Now
100 mg 14023 $70 Buy Now
Salermide SIRT Inhibitor 25 mg 14124 $275 Buy Now
5 mg 14125 $105 Buy Now
SirtAct SIRT1 Activator 25 mg 14080 $670 Buy Now
5 mg 14081 $160 Buy Now
Sirtinol SIRT Inhibitor 25 mg 14074 $485 Buy Now
5 mg 14075 $120 Buy Now
Splitomicin Sir2p (yeast Sirt1 homolog) Inhibitor 25 mg 14086 $250 Buy Now
5 mg 14087 $70 Buy Now
Triacetyl resveratrol SIRT Activator 250 mg 14116 $350 Buy Now
50 mg 14117 $140 Buy Now