Valproic Acid, sodium salt

Aliases: Sodium valproate, 2-Propylpentanoic acid Na
Catalog No: 14021 Format: 5 g $45 Buy
Application: Histone Acetylation (HAT & HDAC)

Chemical Properties

MW = 166.2
C8H15O2Na
CAS 1069-66-5
>98% (TLC); NMR (Conforms)

Description

Histone deacetylase inhibitor (IC50 = 400 µM). Demonstrates neuroprotective, anti-cancer and anti-inflammatory activity. Inhibits Aβ production and neuritic plaque formation in Alzheimer's mouse models. Clinically useful anti-convulsant.

Contents

White powder. May be dissolved in water (50 mg/ml).

Storage Conditions

Store desiccated as supplied at 4°C for up to 2 years. Store solutions at -20°C for up to 3 months.

References

1. CJ Phiel et al. J. Biol. Chem. 2001 276:36734
2. HJ Kim et al. J. Pharmacol. Exp. Ther. 2007, 321:892
3. H Qing et al. J. Exp. Med. 2008, 205:2781

 
Chemical structure of valproic acid, sodium salt.

Chemical structure of Valproic Acid, sodium salt.