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Vorinostat (SAHA)

Aliases: Suberoylanilide-hydroxamic acid, SAHA
Catalog No: 14026 Format: 50 mg $350 Buy Now
Catalog No: 14027 Format: 10 mg $95 Buy Now
Application: Histone Acetylation (HAT & HDAC)

for Vorinostat (SAHA)Chemical Properties

MW = 264.3
C14H20N2O3
CAS 149647-78-9
>98% (TLC); NMR (Conforms)

for Vorinostat (SAHA)Description

Potent and selective histone deacetylase inhibitor (ref 1). Induces apoptosis in a variety of tumor cell lines (ref 2). Synergizes with kinase inhibitors to kill CNS tumor cells (ref 3). Prevents diabetes in a mouse model by immunoregulation and β-cell pretection (ref4). Cell permeable.

for Vorinostat (SAHA)Contents

White powder. May be dissolved in DMSO (50 mg/ml); Ethanol (2 mg/ml).

for Vorinostat (SAHA)Storage Conditions

Store desiccated as supplied at room temperature for up to 5 years. Store solutions at -20°C for up to 1 month.

for Vorinostat (SAHA)References

1. JA Vrana et al. Oncogene 1999, 18:7016
2. LM Butler et al. Proc. Natl. Acad. Sci. USA 2002, 99:11700
3. Y Tang et al. Cancer Biol. Ther. 2012, 13:567
4. DP Christensen et al. Proc. Natl. Acad. Sci. USA 2014, 111:1055

 
Chemical structure of Vorinostat (SAHA).

Chemical structure of Vorinostat (SAHA).

 

Technical Data Sheet

Vorinostat (SAHA)
 

Data Thumbnails

Chemical structure of Vorinostat (SAHA).

Chemical structure of Vorinostat (SAHA).
(Click image to enlarge.)