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MS-275

Aliases: Entinostat, Pyridin-3-ylmethyl 4-((2-aminophenyl)carbamoyl)benzylcarbamate
Catalog No: 14042 Format: 25 mg $280 Buy Now
Catalog No: 14043 Format: 5 mg $90 Buy Now
Application: Histone Acetylation (HAT & HDAC)

for MS-275Chemical Properties

MW = 376.4
C21H20N4O3
CAS 209783-80-2
≥98% (TLC); NMR (Conforms)

for MS-275Description

A potent and selective non-hydroxamate HDAC inhibitor. Considered to be a class I selective inhibitor but displays some selectivity amongst class I members; HDAC1 (IC50 = 0.3 M); HDAC3 (IC50 = 8 M) with no inhibition of HDAC 8 (at > 100 M) (ref 1). Induces hyperacetylation of nuclear histones in tumor cells resulting in inhibition of proliferation of a variety of human tumor cell lines (ref 2). Protects p53-deficient mice against ischemic injury (ref 3). Suppresses the p38 MAP kinase pathway in rheumatoid arthritic synovial fibroblasts (ref 4). Active in vivo.

for MS-275Contents

Pale yellow powder. May be dissolved in DMSO (25 mg/ml, warm).

for MS-275Storage Conditions

Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 week.

for MS-275References

1. E Hu et al. J. Pharmacol. Exp. Ther. 2003, 307:720
2. A Saito et al. Proc. Natl. Acad. Sci. USA 1999, 96:4592
3. SP Murphy et al. J. Neurochem. 2013, Oct 21 epub
4. QY Choo et al. Molecules 2013, 18:14085

 
Chemical structure of MS-275.

Chemical structure of MS-275.

 

Technical Data Sheet

MS-275
 

Data Thumbnails

Chemical structure of MS-275.

Chemical structure of MS-275.
(Click image to enlarge.)