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Aliases: C-646, 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid
Catalog No: 14052 Format: 25 mg $430 Buy Now
Catalog No: 14053 Format: 5 mg $120 Buy Now
Application: Histone Acetylation (HAT & HDAC)

for C646Chemical Properties

MW = 445.4
CAS 328968-36-1
>98% (TLC); NMR (Conforms)

for C646Description

Potent and selective inhibitor of the histone acetyltransferase p300/CBP (Ki = 400 nM)(ref 1). Induces apoptosis in prostate cancer cells (ref 2). Enhances fear extinction memory and synaptic plasticity in mice (ref 3). Promotes tau deacetylation reducing levels of pathogenic p-tau (ref 4). Cell permeable.

for C646Contents

Orange powder. May be dissolved in DMSO (10 mg/ml).

for C646Storage Conditions

Store desiccated as supplied at 4°C for up to 2 years. Store solutions at -20°C for up to 2 months.

for C646References

1. EM Bowers et al. Chem. Biol. 2010, 17:471
2. FR Santer et al. Mol. Cancer Ther. 2011, 10:1644
3. R Marek et al. J. Neurosci. 2011, 31:7486
4. S-W Min et al. Neuron 2010, 67:953

Chemical structure of C646.

Chemical structure of C646


Technical Data Sheet


Data Thumbnails

Chemical structure of C646.

Chemical structure of C646.
(Click image to enlarge.)