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ML-324

Aliases: N-(3-(dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide
Catalog No: 14078 Format: 25 mg $380 Buy Now
Catalog No: 14079 Format: 5 mg $100 Buy Now
Application: Histone Methylation (HMT & HDM)

for ML-324Chemical Properties

MW = 349.4
C21H23N3O2
CAS Not found
>98% (TLC); NMR (Conforms)

for ML-324Description

Inhibits JMJD2 histone demethylases (JMJD2 IC50 = 920 nM). Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC50 ~ 10 M) and abrogates infection. Represses the reactivation of HSV from the latent state in sensory neurons (ref 1). Cell permeable.

for ML-324Contents

Light brown powder. May be dissolved in DMSO (20 mg/ml, warm); Ethanol (6 mg/ml, warm).

for ML-324Storage Conditions

Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 month.

for ML-324References

1. Yu Liang et al. Sci. Transl. Med. 2013, 5:167ra5

 
Chemical structure of ML-324.

Chemical structure of ML-324.

 

Technical Data Sheet

ML-324
 

Data Thumbnails

Chemical structure of ML-324.

Chemical structure of ML-324.
(Click image to enlarge.)