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Epigenetics & Chromatin

Tubastatin A hydrochloride

Aliases: Tubastatin A, N-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide, hydrochloride
Catalog No: 14084 Format: 25 mg $395 Buy Now
Catalog No: 14085 Format: 5 mg $115 Buy Now
Application: Histone Acetylation (HAT & HDAC)

for Tubastatin A hydrochlorideChemical Properties

MW = 371.9
C20H21N3O2• HCl
CAS 1310693-92-5
99% (HPLC); NMR (Conforms)

for Tubastatin A hydrochlorideDescription

Potent and selective histone deacetylase 6 (HDAC 6) inhibitor (IC50 = 15 nm; >1000-fold selective against other HDACs and 60-fold for HDAC8))(ref 1). Inhibits TNFα (IC50 = 272 nm) and IL-6 (IC50 = 712 nm) in LPS-stimulated human macrophages and displays anti-inflammatory activity in animal models (ref 2). Improves survival in animal models of sepsis (ref 3). Improves cognition in Alzheimers disease transgenic mice (ref 4). Cell permeable.

for Tubastatin A hydrochlorideContents

White powder. May be dissolved in DMSO (50 mg/ml).

for Tubastatin A hydrochlorideStorage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.

for Tubastatin A hydrochlorideReferences

1. KV Butler et al. J. Am. Chem. Soc. 2010, 132:10842
2. S Vishwakarma et al. Int. Immunopharmacol. 2013, 16:72
3. T Zhao et al. Surg. Res. 2014, 190:647
4. L Zhang et al. J. Alzheimers Dis. 2014, 41:1193

 
Chemical structure of Tubastatin A hydrochloride.

Chemical structure of Tubastatin A hydrochloride.

Technical Data Sheet

Tubastatin A hydrochloride
 

Data Thumbnails

Chemical structure of Tubastatin A hydrochloride.

Chemical structure of Tubastatin A hydrochloride.
(Click image to enlarge.)