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RG108

Aliases: RG-108, N-Phthalyl-L-tryptophan; or (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid
Catalog No: 14104 Format: 25 mg $245 Buy Now
Catalog No: 14105 Format: 5 mg $65 Buy Now
Application: DNA Methylation

for RG108Chemical Properties

MW = 334.3
C19H14N2O4
CAS 48208-26-0
MP = 104°C
>98% (TLC); NMR (Conforms)

for RG108Description

A non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM)(ref 1). Inhibits DNA methylation in human and tumor cell lines without toxicity (ref 2). Enhances the reversion of neural progenitor cells to the pluripotent state (ref 3).

for RG108Contents

Tan powder. May be dissolved in DMSO (100 mg/ml); Ethanol (100 mg/ml).

for RG108Storage Conditions

Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 1 month.

for RG108References

1. B Brueckner et al. Cancer Res. 2005, 65:6305
2. C Stresemann et al. Cancer Res. 2006, 66:2794
3. I Szablowska-Gadomska et al. Acta. Neurobiol. Exp. 2012, 72:337

 
Chemical structure of RG108.

Chemical structure of RG108.

 

Technical Data Sheet

RG108
 

Data Thumbnails

Chemical structure of RG108.

Chemical structure of RG108.
(Click image to enlarge.)