2'-Deoxy-5-fluorocytidine

Aliases: 2'-Deoxy-5-fluorocytidine, 5-Fluoro-2'-deoxycytidine; FCDR; FdCyd; NSC-48006
Catalog No: 14108 Format: 250 mg $420 Buy
Catalog No: 14109 Format: 50 mg $105 Buy
Application: DNA Methylation

Chemical Properties

MW = 245.2
C9H12FN3O4
CAS 10356-76-0
MP = 196°C
>98% (TLC); NMR (Conforms)

Description

A DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors (ref 1). Like 5-Azacytidine and decitabine, 2'-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation (ref 2). It blocks proliferation in colon cancer-derived HCT-116 cells by activating DNA response pathways (ref 3). It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo (ref 4).

Contents

White solid. May be dissolved in DMSO (20 mg/ml).

Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.

References

1. J Ren et al. Cell Signal. 2011, 23:1082
2. H Gowher et al. Cancer Biol. Ther. 2004, 3:1062
3. Q Zhao et al. Springerplus 2002, 1:65
4. Y Kumaki et al. Antiviral Res. 2011, 92:329

 
Chemical structure of 2'-Deoxy-5-fluorocytidine.

Chemical structure of 2'-Deoxy-5-fluorocytidine.