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SGC707

Aliases: 1-Isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-urea, SGC707
Catalog No: 14130 Format: 25 mg $305 Buy Now
Catalog No: 14131 Format: 5 mg $80 Buy Now
Application: Histone Methylation (HMT & HDM)

for SGC707Chemical Properties

MW = 298.3
C16H18N4O2
CAS 1687736-54-4
MP = 233-235°C
>98% (TLC); NMR (Conforms)

for SGC707Description

Pharmacology: Potent and selective allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3)(ref 1). IC50 = 31 nM and selective against 31 other methyltransferases. An extremely useful probe for investigating the role of PRMT3 in normal and pathophysiology. Cell permeable and active in vivo.

for SGC707Contents

Beige crystalline powder. May be dissolved in DMSO (35 mg/ml).

for SGC707Storage Conditions

Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.

for SGC707References

1. HU Kaniskan et al. Angew.Chem. Int. Ed. Engl. 2015, 54:5166<

 
Chemical structure of SGC707.

Chemical structure of SGC707.

 

Technical Data Sheet

SGC707
 

Data Thumbnails

Chemical structure of SGC707.

Chemical structure of SGC707 (click to enlarge.)