Active Motif,
Tools to analyze nuclear function,
Your CartYour Cart 0 items
Recombinant Proteins & Enzymes

Recombinant PRDM5 protein

Aliases: BCS2, PFM2
Catalog No: 31494 Format: 20 µg $395 Buy Now
Expressed In: Baculovirus Protein Species: Human

Request a quote for a bulk orderBulk Order Button


for Recombinant PRDM5 proteinContents

Full length recombinant PRDM5 protein was expressed in Sf9 cells and is supplied in 25 mM Hepes pH 7.5, 400 mM NaCl, 5% Glycerol, 0.04% Triton X-100, 0.2 mM TCEP. Please refer to product insert upon arrival for lot-specific concentration.

for Recombinant PRDM5 proteinBackground

PRDM5 (PR Domain Containing 5) is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Mutations of PRDM5 causes Type 2 brittle cornea syndrome (BCS2) which is an inherited connective tissue disease with a devastating ocular phenotype through histone and DNA methylation. PRDM5 is a relevant tumour suppressor gene that is frequently targeted in colorectal tumourigenesis. Promoter methylation-mediated downregulation of PRDM5 contributes to the development of lung squamous cell carcinoma. It is a sequence-specific DNA-binding transcription factor and represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.

for Recombinant PRDM5 proteinApplication Notes

Recombinant PRDM5 is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.

for Recombinant PRDM5 proteinProtein Details

Recombinant PRDM5 protein (accession number NP_061169.2) was expressed in Sf9 cells and contains an N-terminal FLAG-Tag with a molecular weight of 73.1 kDa. The recombinant protein is >85% pure by SDS-PAGE.

 
PRDM5 protein Coomassie gel

Recombinant PRDM5 protein gel
PRDM5 protein was run on an 8% SDS-PAGE gel and stained with Coomassie blue.

for Recombinant PRDM5 proteinStorage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for Recombinant PRDM5 proteinGuarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.

 

Technical Data Sheet

Recombinant PRDM5 protein
 

Data Thumbnails

PRDM5 protein Coomassie gel

PRDM5 protein Coomassie gel.
(Click image to enlarge and see details).