APEXL2 antibody (pAb)

for APEXL2 antibody (pAb)Background

APEXL2 (APEX2, apurinic endonuclease-like 2 or apyrimidinic endonuclease-like 2) is a multifunctional DNA repair enzyme. The main role of APE is to create a nick in the phosphodiester backbone of the AP site that is created when DNA glycosylase removes the damaged base. Four types of APE (AP endonucleases) are classified according to their site of incision. APEXL2 (APEX2) is a Class II AP endonuclease that cleaves the phosphodiester backbone 5′ to the AP site; it may also be present in the mitochondria.

for APEXL2 antibody (pAb)Immunogen

This antibody was raised against a synthetic peptide corresponding to human APEXL2.

for APEXL2 antibody (pAb)Application Notes

This APEXL2 antibody has been validated for use in Western blotting (1:500 - 1:1,000 dilution). For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all Blotto solutions may also reduce background. Individual optimization may be required.

for APEXL2 antibody (pAb)Buffer

PBS containing 0.02% sodium azide. Sodium azide is highly toxic.

for APEXL2 antibody (pAb)Positive Control

Active Motif's HeLa whole-cell extract (Catalog No. 40050) can be used as a positive control for APEXL2 antibody.

for APEXL2 antibody (pAb)Storage

Antibodies in solution can be stored at -80°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for APEXL2 antibody (pAb)Guarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.