JMJD2D antibody (pAb)

for JMJD2D antibody (pAb)Background

JMJD2D (KDM4D) is a histone demethylase located in the nucleus that specifically demethylates Lysine 9 of Histone H3, thereby playing a central role in the histone code. JMJD2D (KDM4D) demethylates both di- or trimethylated histone H3 Lys 9, while it has no activity on monomethylated residues. The demethylation reaction of the Lys residue generates formaldehyde and succinate as a by product. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D (KDM4D) may be involved in carcinogenesis.

for JMJD2D antibody (pAb)Immunogen

This JMJD2D antibody was raised against a peptide corresponding to amino acids 337-359 of human JMJD2D.

for JMJD2D antibody (pAb)Application Notes

This JMJD2D antibody has been validated for use in Western blotting (1:500 - 1:2,000 dilution).

for JMJD2D antibody (pAb)Buffer

Rabbit IgG, 30% glycerol, 0.035% sodium azide.

for JMJD2D antibody (pAb)Positive Control

Active Motif's HeLa nuclear extract (Catalog No. 36010) can be used as a positive control for JMJD2D antibody.

for JMJD2D antibody (pAb)Storage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for JMJD2D antibody (pAb)Guarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.