KLF4 antibody (pAb)

for KLF4 antibody (pAb)Background

KLF4 (Kruppel-like factor 4) is a transcription factor that binds GC-rich DNA sequences having a consensus core DNA binding sequence of CACCC. It is a member of the Kruppel-like factor (KLF) family, highly expressed in the gastrointestinal tract, skin and other epithelial tissues. Krüppel-like factors are a family of zinc-finger transcription factors that play important roles in many fundamental biologic processes including development, proliferation, differentiation, and apoptosis. KLF4 can function both as an activator and repressor of transcription, depending on the gene targeted. Generally, KLF4 serves as a cell cycle regulator, and it may be a tumor suppressor. KLF4 also appears to function as an oncogene in some situations. Additionally, overexpression of KLF4 (along with Oct3/4, Sox2 and c-Myc) can transform mouse fibroblasts into a state resembling embryonic stem cells (ES cells), referred to as Induced Pluripotency.

for KLF4 antibody (pAb)Immunogen

This KLF4 antibody was raised against recombinant full length human KLF4.

for KLF4 antibody (pAb)Application Notes

This KLF4 antibody has been validated in Western blot (1:2,000 - 1:5,000 dilution).

for KLF4 antibody (pAb)Buffer

Purified IgG in PBS, 30% glycerol, 0.035% sodium azide.

for KLF4 antibody (pAb)Storage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for KLF4 antibody (pAb)Guarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.