TBK1 antibody (mAb)

for TBK1 antibody (mAb)Background

TBK1 – TANK-binding kinase 1 is a regulator of the NFκB (NFκB p50 and NFκB p65) signaling pathway. NFκB signaling is controlled to a large extent by the sequestration of the NFκB complex in the cytoplasm by its association with one of the IκB family of proteins. IκB is phosphorylated by the IkB Kinase (IKK) complex, resulting in the degradation of IκB and the nuclear translocation of NFκB. TANK is an IκB family member that is specifically recognized and phosphorylated by TBK1, leading to the destruction of TANK and the activation of the NFκB pathway.

for TBK1 antibody (mAb)Immunogen

This antibody was raised against a peptide corresponding to amino acid residues 563-577 of human TBK1.

for TBK1 antibody (mAb)Application Notes

This TBK1 antibody has been validated for use in Western blotting (1 - 2 µg/ml dilution). For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all Blotto solutions may also reduce background. Individual optimization may be required.

for TBK1 antibody (mAb)Buffer

PBS containing 0.02% sodium azide. Sodium azide is highly toxic.

for TBK1 antibody (mAb)Positive Control

Active Motif's 293 nuclear extract (Catalog No. 36033) can be used as a positive control for TBK1 antibody.

for TBK1 antibody (mAb)Storage

Antibodies in solution can be stored at -80°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for TBK1 antibody (mAb)Guarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.