PPAR-γ antibody (mAb)

for PPAR-gamma antibody (mAb) (Clone 3PP-1H4)Background

Peroxisome Proliferator-Activated Receptors (PPARs) are nuclear receptors involved in lipid transport and metabolism. As such, their roles in chronic diseases such as diabetes, obesity, atherosclerosis and cancer are heavily investigated. Transcriptional activity of PPARs is regulated by fatty acid binding. Three PPAR isotypes have been identified: α, δ and γ. PPAR-γ stimulates lipolysis of circulating triglycerides and the subsequent uptake of fatty acids into adipose cells. PPARs bind to peroxisome proliferator response elements (PPREs) as heterodimers with the retinoid X receptor (RXR).

for PPAR-gamma antibody (mAb) (Clone 3PP-1H4)Immunogen

This PPAR-gamma antibody was raised against a peptide within the N-terminal region of human PPAR gamma 1 and gamma 2.

for PPAR-gamma antibody (mAb) (Clone 3PP-1H4)Application Notes

This PPAR-γ antibody has been validated for use in in immunofluorescence and Western blot (0.5 - 2 µg/ml dilution). See references for details.

for PPAR-gamma antibody (mAb) (Clone 3PP-1H4)Buffer

Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 32 mM glycine, 0.07 mM EDTA, 30% glycerol, and 0.035% sodium azide.

for PPAR-gamma antibody (mAb) (Clone 3PP-1H4)Positive Control

Active Motif's THP-1 nuclear extract (Catalog No. 36076) can be used as a positive control for PPAR-γ antibody.

for PPAR-gamma antibody (mAb) (Clone 3PP-1H4)References

This antibody has been used in the following references:
WB: Matthews WB et al (2005) J Nucl Med 46: 1719-1726; Schipper BM et al (2008) Ann Plast Surg 60: 538-544.

for PPAR-gamma antibody (mAb) (Clone 3PP-1H4)Storage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for PPAR-gamma antibody (mAb) (Clone 3PP-1H4)Guarantee

This product is guaranteed for 6 months from date of arrival.