BLIMP1 / PRDM1 antibody (pAb)

for BLIMP1 / PRDM1 antibody (pAb)Background

BLIMP1 / PRDM1 (Beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1 Positive regulatory domain I-binding factor 1) is a DNA sequence-specific transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene, as well as other genes. It is required for maturation of B-lymphocytes into immunoglobin secreting plasma cells through direct repression of transcription factors such as Pax5, Bcl6, and Myc, which function in the lineage commitment and proliferation of B cells. BLIMP1 / PRDM1 contains an N-terminal SET domain and four C-terminal C2H2-type zinc-finger motifs. It is also required for effector T-cell function and for the specification of primordial germ cell lineages.

for BLIMP1 / PRDM1 antibody (pAb)Immunogen

This BLIMP1 / PRDM1 antibody was raised against a peptide within the N-terminal half of human BLIMP1 / PRDM1.

for BLIMP1 / PRDM1 antibody (pAb)Application Notes

This BLIMP1 / PRDM1 antibody has been validated for use in Western blotting (1:500 - 1:1,000).

for BLIMP1 / PRDM1 antibody (pAb)Buffer

Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 32 mM glycine, 0.07 mM EDTA, 30% glycerol, and 0.035% sodium azide.

for BLIMP1 / PRDM1 antibody (pAb)Positive Control

Active Motif's Saos-2 nuclear extract (Catalog No. 36025) can be used as a positive control for BLIMP1 / PRDM1 antibody.

for BLIMP1 / PRDM1 antibody (pAb)Storage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for BLIMP1 / PRDM1 antibody (pAb)Guarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.