c-Myc antibody (mAb)
|Aliases: MRTL, MYCC, c-Myc, bHLHe39|
|Catalog No: 61075||Format: 100 µg||$370||Buy Now|
|Catalog No: 61076||Format: 10 µg||$80||Buy Now|
for c-Myc antibody (mAb) (Clone 6A10)Application Notes
See references for experimental details. Individual optimization may be required.
for c-Myc antibody (mAb) (Clone 6A10)Immunogen
This c-Myc antibody was raised against a recombinant protein corresponding to amino acids 1-262 of human c-Myc protein.
for c-Myc antibody (mAb) (Clone 6A10)Buffer
Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
for c-Myc antibody (mAb) (Clone 6A10)References
Click on the Applications below to view references for this antibody:
IP & WB
Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP. Vervoorts J. et al. (2003) EMBO Rep. 4(5): 484-90
Identification and characterization of specific DNA-binding complexes containing members of the Myc/Max/Mad network of transcriptional regulators. Sommer A. et al. (1998) J Biol Chem. 273(12): 6632-42
for c-Myc antibody (mAb) (Clone 6A10)Background
c-Myc (Myc) is a sequence specific DNA binding transcription factor that regulates gene expression, especially genes involved in cell division. Myc family members contain a basic Helix-Loop-Helix leucine zipper (bHLHZ) domain. Myc family proteins associated with thousands of genes, especially those involved in cell growth and proliferation. c-Myc serves as an integrator of signal transduction, linking extracellular signals to an acute cellular growth response. Mutations and overexpression of c-Myc are associated with cell proliferation and cancer.
for c-Myc antibody (mAb) (Clone 6A10)Storage
Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
for c-Myc antibody (mAb) (Clone 6A10)Guarantee
This product is guaranteed for 6 months from date of receipt.
This product is for research use only and is not for use in diagnostic procedures.
- ChIP = Chromatin Immunoprecipitation;
- DB = Dot Blot;
- ELISA = Enzyme-linked Immunosorbent Assay;
- EMSA = Electrophoretic Mobility Shift Assay
- FACS = Flow Cytometry;
- ICC = Immunocytochemistry;
- IF = Immunofluorescence;
- IHC = Immunohistochemistry;
- IP = Immunoprecipitation;
- MeDIP = Methyl-DNA Immunoprecipitation;
- TR-FRET = Time-Resolved Fluorescence Resonance Energy Transfer;
- WB = Western Blotting