c-Myc antibody (mAb)

for c-Myc antibody (mAb) (Clone 6A10)Background

c-Myc (Myc) is a sequence specific DNA binding transcription factor that regulates gene expression, especially genes involved in cell division. Myc family members contain a basic Helix-Loop-Helix leucine zipper (bHLHZ) domain. Myc family proteins associated with thousands of genes, especially those involved in cell growth and proliferation. c-Myc serves as an integrator of signal transduction, linking extracellular signals to an acute cellular growth response. Mutations and overexpression of c-Myc are associated with cell proliferation and cancer.

for c-Myc antibody (mAb) (Clone 6A10)Immunogen

This c-Myc antibody was raised against a recombinant protein corresponding to amino acids 1-262 of human c-Myc protein.

for c-Myc antibody (mAb) (Clone 6A10)Application Notes

This c-Myc antibody has been validated for use in EMSA, immunoprecipitation and Western blotting. See references for more details.

for c-Myc antibody (mAb) (Clone 6A10)Buffer

Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 32 mM glycine, 0.07 mM EDTA, 30% glycerol, and 0.035% sodium azide.

for c-Myc antibody (mAb) (Clone 6A10)References

This antibody has been used in the following references:
EMSA: Sommer A et al (1998) J Biol Chem 273: 6632-6642.
IP: Vervoorts J et al (2003) EMBO Reports 4: 484-490.
WB: Vervoorts J et al (2003) EMBO Reports 4: 484-490.

for c-Myc antibody (mAb) (Clone 6A10)Storage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for c-Myc antibody (mAb) (Clone 6A10)Guarantee

This product is guaranteed for 6 months from date of arrival.