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Antibodies

Bcl6 antibody (mAb)

Clone: IG191E
Aliases: B-Cell CLL/Lymphoma 6, BCL5, LAZ3, BCL6A, ZNF51, ZBTB27
Catalog No: 61193 Format: 100 µg $410 Buy Now
Catalog No: 61194 Format: 10 µg $95 Buy Now

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Antibody Type:Monoclonal
Isotype:IgG1
Purification:Protein G Chromatography
Host:Mouse
Molecular Weight:80 kDa
Reactivity:Human

Applications

Western Blot Validated Immunohistochemistry Validated

for Bcl6 antibody (mAb) (Clone IG191E)Application Notes


Published Applications:
IHC
WB
See references for more information. Individual optimization may be required.

for Bcl6 antibody (mAb) (Clone IG191E)Immunogen

This Bcl6 antibody was raised against a full-length protein corresponding to human Bcl6.

for Bcl6 antibody (mAb) (Clone IG191E)Buffer

Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.

for Bcl6 antibody (mAb) (Clone IG191E)References

for Bcl6 antibody (mAb) (Clone IG191E)Background

Bcl6 (B-cell lymphoma 6 protein, Bcl5, LAZ3, ZBTB27, ZNF51) is sequence-specific transcriptional repressor that is required for the formation of lymph node germinal centers (GC). Bcl6 is a member of the BTB-POZ family of transcriptional regulators and contains six Kruppel-type zinc fingers. The POZ domain in the amino terminus of Bcl6 is involved in the recruitment of corepressor proteins including NCoR, BCoR, SMRT, Mi-2/NURD and several HDACs. Bcl6 promotes proliferative expansion of B-cells in the germinal center through repression of genes regulating cell cycle and differentiation. Bcl6 also suppresses the DNA damage response, to prevent class-switch recombination being repaired. Unregulated expression of Bcl6 is involved in the development of many B-cell lymphomas.

for Bcl6 antibody (mAb) (Clone IG191E)Storage

Some products may be shipped at room temperature. This will not affect their stability or performance. Upon receipt, unconjugated antibodies may be stored at -20°C for up to 2 years. Fluorophore- & enzyme-conjugated antibodies should be stored at 4°C. Fluorophore-conjugated antibodies should be protected from light. Keep reagents on ice when not in storage; to avoid repeated freeze/thaw cycles, we recommend aliquoting items that will be stored frozen into single-use fractions prior to freezing.

for Bcl6 antibody (mAb) (Clone IG191E)Guarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.

Application Key

  • ChIP = Chromatin Immunoprecipitation;
  • DB = Dot Blot;
  • ELISA = Enzyme-linked Immunosorbent Assay;
  • EMSA = Electrophoretic Mobility Shift Assay
  • FC = Flow Cytometry;
  • ICC = Immunocytochemistry;
  • IF = Immunofluorescence;
  • IHC = Immunohistochemistry;
  • IP = Immunoprecipitation;
  • MeDIP = Methyl-DNA Immunoprecipitation;
  • TR-FRET = Time-Resolved Fluorescence Resonance Energy Transfer;
  • WB = Western Blotting
 

Technical Data Sheet

Bcl6 antibody (mAb)