BCL11A antibody (mAb)

for BCL11A antibody (mAb) (Clone BCL11A/123 )Background

BCL11A (B-cell CLL/lymphoma 11A) is a transcriptional regulator, a myeloid and B-cell proto-oncogene and plays important roles in leukemogenesis and hematopoiesis. BCL11A is involved in regulating hemoglobin gene expression. BCL11A regulates hemoglobin gene switching during fetal development and silencing of γ-globin expression in adults. BCL11A interacts with the Mi-2/NuRD chromatin remodeling complexes, as well as the erythroid transcription factors GATA1 and FOG1. Abundant expression of full-length forms of BCL11A is developmentally restricted to adult erythroid cells.

for BCL11A antibody (mAb) (Clone BCL11A/123 )Immunogen

This BCL11A antibody was raised against a recombinant protein corresponding to amino acids 637-835 of BCL11A-XL (B-cell lymphoma/leukemia 11A extra long form).

for BCL11A antibody (mAb) (Clone BCL11A/123 )Application Notes

This BCL11A antibody has been validated for use in Western blotting, immunohistochemistry and Immunoflourescence. See references for more details.

for BCL11A antibody (mAb) (Clone BCL11A/123 )Buffer

Purified IgG in PBS with 30% glycerol and 0.035% sodium azide.

for BCL11A antibody (mAb) (Clone BCL11A/123 )References

The use of this antibody is described in the following references:
WB: Pulford K, et al (2006) Leukemia 20:1439-1441
IHC: Weniger MA, et al (2008) Blood 111:3778-3792
IF: Liu H, et al (2006) Mol Cancer 16; 5-18

for BCL11A antibody (mAb) (Clone BCL11A/123 )Storage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for BCL11A antibody (mAb) (Clone BCL11A/123 )Guarantee

This product is guaranteed for 6 months from date of arrival.