RAP1 / TERF2IP antibody (mAb)

for RAP1 / TERF2IP antibody (mAb) (Clone 4C8)Background

RAP1 / TERF2IP (Repressor/activator protein 1, Telomeric repeat-binding factor 2-interacting protein 1) is a protein associated with telomeres that acts both as a modulator of telomere function and as a regulator of transcription. RAP1 is a component of the shelterin (telosome) protein complex and is involved in the regulation of telomere length and serves to protect telomeric repeats from degradation. In contrast to other components of the shelterin complex, RAP1 is dispensable for telomere end-capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. RAP1 is recruited to telomeric repeats via its interaction with TERF2. Independent of its function in telomeres, RAP1 also acts as a transcriptional regulator. It is recruited to non-telomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. RAP1 is also present in the cytoplasm and associates with the IκB-kinase (IKK) complex and acts as a regulator of the NFκB signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activation of the expression of NFκB target genes.

for RAP1 / TERF2IP antibody (mAb) (Clone 4C8)Immunogen

This RAP1 / TERF2IP antibody was raised against a protein corresponding to full length human RAP1 / TERF2IP.

for RAP1 / TERF2IP antibody (mAb) (Clone 4C8)Application Notes

This RAP1 / TERF2IP antibody has been validated for use in Western blotting. See references for more details.

for RAP1 / TERF2IP antibody (mAb) (Clone 4C8)Buffer

Purified IgG in PBS with 30% glycerol and 0.035% sodium azide.

for RAP1 / TERF2IP antibody (mAb) (Clone 4C8)References

The use of this antibody is described in the following reference:
WB: Bombarde, O et al (2010) Embro J. 29:1573-1584

for RAP1 / TERF2IP antibody (mAb) (Clone 4C8)Storage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for RAP1 / TERF2IP antibody (mAb) (Clone 4C8)Guarantee

This product is guaranteed for 6 months from date of arrival.