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Recombinant Proteins & Enzymes

Recombinant c-Myc / MAX complex

Catalog No: 81087 Format: 20 µg $395 Buy Now
Catalog No: 81787 Format: 1 mg $3,800 Buy Now
Expressed In: Baculovirus Protein Species: Human

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for Recombinant c-Myc / MAX complexContents

Recombinant c-Myc / MAX Complex is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10% glycerol, 0.04% Triton X-100 and 0.5 mM TCEP. Please refer to product insert upon arrival for lot-specific concentration.

for Recombinant c-Myc / MAX complexBackground

c-Myc (MYC Proto-Oncogene, BHLH Transcription Factor), also known as MYCC or MRTL, is a transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5-CAC[GA]TG-3. Diseases associated with MYC include Burkitt Lymphoma and Precursor T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and IL-2 Pathway. c-Myc can activate the transcription of growth-related genes. MAX (MYC Associated Factor X), also known as BHLHd4, is a member of transcription regulators. MAX forms a sequence-specific DNA-binding protein complex with MYC or MAD, and the MYC / MAX complex is a transcriptional activator, whereas the MAD / MAX complex is a repressor. It may repress transcription via the recruitment of a chromatin remodeling complex containing H3 Lys-9 histone methyltransferase activity. c-Myc / MAX complex can specifically recognize the core sequence 5-CAC[GA]TG-3 and bind to the E box DNA consensus sequence and regulates the transcription of specific target genes.

for Recombinant c-Myc / MAX complexApplication Notes

This protein is suitable for use in protein-protein interaction,in vitro transcription assay, binding assay.

for Recombinant c-Myc / MAX complexProtein Details

Recombinant c-Myc / MAX Complex that includes human c-Myc amino acids 2 - 454 (accession number NP_002458.2) with an N-terminal FLAG tag and full length human MAX protein (accession number NP_660087.1) with an N-terminal 6×His tag was expressed in Sf9 cells. The molecular weights of c-Myc (2 - 454) and MAX are 51.8 kDa and 20.6 kDa, respectively.

 
Recombinant c-Myc / MAX Complex gel

Recombinant c-Myc / MAX Complex
10% SDS-PAGE Coomassie staining
Molecular Weights: c-Myc: 51.8 kDa MAX: 20.6 kDa

Purity: >85%

for Recombinant c-Myc / MAX complexStorage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for Recombinant c-Myc / MAX complexGuarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.

 

Technical Data Sheet

Recombinant c-Myc / MAX complex
 

Data Thumbnails

Recombinant c-Myc / MAX Complex gel

Recombinant c-Myc / MAX Complex gel
(Click to enlarge and view details)