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Recombinant Proteins & Enzymes

Recombinant STAT3 protein

Catalog No: 81095 Format: 20 µg $405 Buy Now
Catalog No: 81895 Format: 1 mg $3,500 Buy Now
Expressed In: Baculovirus Protein Species: Human

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for Recombinant STAT3 proteinContents

Recombinant STAT3 protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10% glycerol, 0.04% Triton X-100 and 0.5 mM TCEP. Please refer to product insert upon arrival for lot-specific concentration.

for Recombinant STAT3 proteinBackground

STAT3 (Signal Transducer And Activator Of Transcription 3), also known as APRF (Acute-Phase Response Factor) or ADMIO, HIES, is a signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, STAT3 can recruit coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. Deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity. STAT3 can bind to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. It also acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells. It is involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. 

for Recombinant STAT3 proteinApplication Notes

This protein is suitable for use in protein-protein interaction, in vitro transcription assay, binding assay.

for Recombinant STAT3 proteinProtein Details

Recombinant human STAT3 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_644805.1) with an N-terminal FLAG tag. The molecular weight of the protein is 89.2 kDa.

 
Recombinant STAT3 protein  gel

Recombinant STAT3 protein gel
10% SDS-PAGE Coomassie staining
MW: 89.2 kDa
Purity: >90%

for Recombinant STAT3 proteinStorage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for Recombinant STAT3 proteinGuarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.

 

Technical Data Sheet

Recombinant STAT3 protein
 

Data Thumbnails

Recombinant STAT3 protein  gel

Recombinant STAT3 protein gel
(Click to enlarge and view details)