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Recombinant Proteins & Enzymes

Recombinant PIK3R1 protein

Catalog No: 81097 Format: 20 µg $405 Buy Now
Catalog No: 81897 Format: 1 mg $3,500 Buy Now
Expressed In: Baculovirus Protein Species: Human

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for Recombinant PIK3R1 proteinContents

Recombinant PIK3R1 protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10% glycerol, 0.04% Triton X-100 and 0.5 mM TCEP. Please refer to product insert upon arrival for lot-specific concentration.

for Recombinant PIK3R1 proteinBackground

PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1), also known as GRB1, p85-ALPHA or p85, is a regulatory subunit of phosphatidylinositol 3-kinase. It can bind to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. It is necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. And it plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB, likewise, plays a role in ITGB2 signaling. PIK3R1 also modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress-and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.

for Recombinant PIK3R1 proteinApplication Notes

This protein is suitable for use in binding assays, inhibitor screening, and selectivity profiling.

for Recombinant PIK3R1 proteinProtein Details

Recombinant human PIK3R1 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_852664.1) with an N-terminal FLAG tag. The molecular weight of the protein is 84.9 kDa.

 
Recombinant PIK3R1 protein gel

Recombinant PIK3R1 protein gel
7.5% SDS-PAGE Coomassie staining
MW: 84.9 kDa
Purity: >95%

for Recombinant PIK3R1 proteinStorage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for Recombinant PIK3R1 proteinGuarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.

 

Technical Data Sheet

Recombinant PIK3R1 protein
 

Data Thumbnails

Recombinant PIK3R1 protein gel

Recombinant PIK3R1 protein gel
(Click to enlarge and view details)