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Recombinant Proteins & Enzymes

Recombinant TMEM173 (STING) (149-379) protein

Catalog No: 81182 Format: 50 µg $395 Buy Now
Catalog No: 81882 Format: 1 mg $2,600 Buy Now
Expressed In: E. coli Protein Species: Human

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for Recombinant TMEM173 (STING) (149-379) proteinContents

Recombinant TMEM173 (STING) (149-379) protein is supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 10% glycerol.

for Recombinant TMEM173 (STING) (149-379) proteinBackground

STING (Stimulator Of Interferon Genes, also known as TMEM173, HMITA, NET23, ERIS, MPYS, MITA, SAVI) is a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. STING is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. It has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. It acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state.

for Recombinant TMEM173 (STING) (149-379) proteinApplication Notes

This protein is useful for the study of protein-protein interaction, screening inhibitors, and selectivity profiling.

for Recombinant TMEM173 (STING) (149-379) proteinProtein Details

Recombinant TMEM173 (STING) (149-379) corresponding to amino acids 149-379 of human STING (accession number NP_938023.1) was expressed in E. coli cells and contains a C-terminal 6×His tag with a molecular weight of 27.3 kDa.

 
Recombinant TMEM173 (STING) (149-379) gel

Recombinant TMEM173 (STING) (149-379) gel
12.5% SDS-PAGE Coomassie staining
M.W.: 27.3 kDa
Purity: ≥ 65%

for Recombinant TMEM173 (STING) (149-379) proteinStorage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for Recombinant TMEM173 (STING) (149-379) proteinGuarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.

 

Technical Data Sheet

Recombinant TMEM173 (STING) (149-379) protein
 

Data Thumbnails

Recombinant TMEM173 (STING) (149-379) gel

Recombinant TMEM173 (STING) (149-379) gel
(Click to enlarge and view details)