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Recombinant Proteins & Enzymes

Histone Methyltransferases (HMTs) and Histone Demethylases (HDMs)

active, recombinant HMT and HDM proteins

Histone methyltransferases (HMT) are histone-modifying enzymes that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues on histone proteins. Methylation of arginine residues is catalyzed by protein arginine methyltransferases (PRMTs) while histone methyltransferases (HMTs) are responsible for lysine methylation. The removal of these histone marks from arginine and lysine residues is catalyzed by protein arginine demethylase (PRDM) and lysine demethylase (KDM) enzymes, respectively.

The methylation of histones is an important post-translational modification that is involved in regulating genome compaction and gene expression. Depending on the amino acid target, methylation can lead to either transcriptional repression or activation.

Active Motif offers a large number of active, recombinant HMT and HDM proteins available in small scale and bulk quantities.

 
Name Expressed In Format Cat No. Price  
Recombinant DOT1L (1-416) protein E. coli 50 µg 31474 $410 Buy Now
1 mg 31874 $2,900 Buy Now
Recombinant EHMT1 (894-1298) protein E. coli 50 µg 31520 $410 Buy Now
1 mg 31920 $2,900 Buy Now
Recombinant EHMT2 (G9a) protein Baculovirus 20 µg 31410 $405 Buy Now
1 mg 31810 $3,500 Buy Now
Recombinant EHMT2 (G9A)-SET (913-1193) protein E. coli 50 µg 31425 $410 Buy Now
1 mg 31825 $2,900 Buy Now
Recombinant EZH1 complex Baculovirus 20 µg 31500 $435 Buy Now
1 mg 31904 $3,800 Buy Now
Recombinant EZH2 protein complex Baculovirus 25 µg 31337 $405 Buy Now
Recombinant FBXL10 / KDM2B protein Baculovirus 20 µg 31455 $410 Buy Now
Recombinant JARID1A / KDM5A protein Baculovirus 20 µg 31431 $410 Buy Now
1 mg 31831 $3,800 Buy Now
Recombinant JARID1B / KDM5B protein Sf9 cells 20 µg 31432 $410 Buy Now
1 mg 31832 $3,800 Buy Now
Recombinant JARID1B / KDM5B (2-751) protein Baculovirus 20 µg 31518 $410 Buy Now
Recombinant JARID1C / KDM5C protein Baculovirus 20 µg 31433 $410 Buy Now
1 mg 31833 $3,800 Buy Now
Recombinant JHDM1D-l protein E. coli 20 µg 31464 $430 Buy Now
Recombinant JMJD1A / KDM3A protein Baculovirus 20 µg 31456 $410 Buy Now
Recombinant JMJD1B / KDM3B protein Baculovirus 20 µg 31429 $410 Buy Now
Recombinant JMJD2A / KDM4A protein Baculovirus 20 µg 31457 $410 Buy Now
1 mg 31857 $3,500 Buy Now
Recombinant JMJD2B / KDM4B protein Baculovirus 20 µg 31501 $410 Buy Now
Recombinant JMJD2C / KDM4C protein Baculovirus 20 µg 31458 $410 Buy Now
1 mg 31858 $3,500 Buy Now
Recombinant JMJD2D / KDM4D protein Baculovirus 20 µg 31459 $410 Buy Now
Recombinant JMJD3 / KDM6B (1043-1682) protein Baculovirus 20 µg 31519 $410 Buy Now
1 mg 31919 $3,500 Buy Now
Recombinant KDM1B / LSD2 protein Baculovirus 20 µg 31479 $410 Buy Now
1 mg 31879 $3,500 Buy Now
Recombinant KDM2A / FBXL11 protein Baculovirus 20 µg 31485 $410 Buy Now
Recombinant KDM6C protein Baculovirus 10 µg 31575 $410 Buy Now
Recombinant KDM7A protein Baculovirus 10 µg 31576 $410 Buy Now
Recombinant KMT2A (MLL1)-SET protein E. coli 50 µg 31419 $410 Buy Now
1 mg 31819 $3,200 Buy Now
Recombinant KMT2A (MLL1) complex E. coli 20 µg 31423 $445 Buy Now
1 mg 31823 $3,500 Buy Now
Recombinant KMT2B (MLL4)-SET protein E. coli 50 µg 31422 $410 Buy Now
1 mg 31822 $3,200 Buy Now
Recombinant KMT2B (MLL4) complex E. coli 20 µg 31499 $435 Buy Now
1 mg 31903 $3,500 Buy Now
Recombinant KMT2C (MLL3) complex E. coli 20 µg 31478 $410 Buy Now
1 mg 31878 $3,500 Buy Now
Recombinant KMT2D (MLL2)-SET protein E. coli 50 µg 31420 $410 Buy Now
1 mg 31820 $3,200 Buy Now
Recombinant KMT2D (MLL2) complex E. coli 20 µg 31498 $435 Buy Now
1 mg 31902 $3,500 Buy Now
Recombinant LSD1 / KDM1A protein E. coli 50 µg 31507 N/A
Recombinant LSD1 / KDM1A protein Baculovirus 20 µg 31426 $410 Buy Now
1 mg 31826 $3,500 Buy Now
Recombinant NSD1-SET protein E. coli 50 µg 31475 $410 Buy Now
1 mg 31775 $3,500 Buy Now
Recombinant NSD2 (MMSET) protein Baculovirus 20 µg 31453 $410 Buy Now
1 mg 31853 $3,800 Buy Now
Recombinant NSD2 (MMSET)-SET protein E. coli 50 µg 31476 $410 Buy Now
1 mg 31776 $3,500 Buy Now
Recombinant NSD2 (E1099K) protein Baculovirus 20 µg 31546 $410 Buy Now
Recombinant NSD2-SET (E1099K) protein E. coli 50 µg 31574 $410 Buy Now
1 mg 31974 $3,500 Buy Now
Recombinant NSD3 (WHSC1L1)-SET protein E. coli 50 µg 31477 $410 Buy Now
1 mg 31877 $3,500 Buy Now
Recombinant PHF8 protein Baculovirus 20 µg 31435 $410 Buy Now
Recombinant PHF8-s protein E. coli 20 µg 31461 N/A
Recombinant PRC2 complex Baculovirus 20 µg 31387 $445 Buy Now
1 mg 31887 $3,800 Buy Now
Recombinant PRC2 EZH2 (Y641C) complex Baculovirus 20 µg 31389 $435 Buy Now
1 mg 31789 $3,800 Buy Now
Recombinant PRC2 EZH2 (Y641F) complex Baculovirus 20 µg 31388 $435 Buy Now
1 mg 31888 $3,800 Buy Now
Recombinant PRC2 EZH2 (Y641N) complex Baculovirus 20 µg 31390 $435 Buy Now
1 mg 31790 $3,800 Buy Now
Recombinant PRC2 EZH2 (A677G) complex Baculovirus 20 µg 31391 $435 Buy Now
1 mg 31891 $3,800 Buy Now
Recombinant PRDM6 protein Baculovirus 20 µg 31495 $410 Buy Now
Recombinant PRDM9 (191-414) protein E. coli 20 µg 31510 $410 Buy Now
Recombinant PRDM10 protein Baculovirus 20 µg 31396 $430 Buy Now
Recombinant PRDM14 protein Baculovirus 20 µg 31397 $430 Buy Now
Recombinant PRMT1 protein Baculovirus 20 µg 31411 $405 Buy Now
Recombinant PRMT2 protein Baculovirus 20 µg 31392 $430 Buy Now
Recombinant PRMT3 protein Baculovirus 20 µg 31412 $405 Buy Now
Recombinant PRMT6 protein Baculovirus 20 µg 31394 $430 Buy Now
Recombinant PRMT7 protein Baculovirus 20 µg 31395 $430 Buy Now
Recombinant vSET (A612L) protein E. coli 5 µg 31402 $405 Buy Now
Recombinant SETD2 (1418-1714) protein E. coli 50 µg 31358 $405 Buy Now
Recombinant SETD2 (1392-2564) protein Baculovirus 20 µg 31399 $430 Buy Now
Recombinant SETD7 protein Baculovirus 20 µg 31496 $410 Buy Now
Recombinant SETD8 protein Baculovirus 20 µg 31427 $410 Buy Now
Recombinant SETDB1 protein Baculovirus 20 µg 31452 $430 Buy Now
Recombinant SETMAR protein Baculovirus 20 µg 31454 $410 Buy Now
Recombinant SMYD1 protein Baculovirus 20 µg 31405 $430 Buy Now
1 mg 31805 $3,800 Buy Now
Recombinant SMYD2 protein Baculovirus 20 µg 31497 $410 Buy Now
Recombinant SMYD3 protein Baculovirus 20 µg 31407 $405 Buy Now
Recombinant SMYD4 protein Baculovirus 20 µg 31408 $405 Buy Now
Recombinant SMYD5 protein Baculovirus 20 µg 31409 $405 Buy Now
Recombinant SUV39H1 protein E. coli 25 µg 31339 N/A
Recombinant SUV39H2 (26-350) protein E. coli 50 µg 31359 N/A
Recombinant SUV420H1 protein E. coli 50 µg 31360 N/A
Recombinant UTX / KDM6A protein Baculovirus 20 µg 31460 $410 Buy Now